摘要
目的:比较国产Z型不锈钢和镍钦记忆合金网状支架在恶性食管狭窄患者中的适用性、有效性、术后副作用、并发症和生物相容性等各项临床验证指标。方法:选择河南省中医院消化内科收治的食管癌合并食管狭窄患者79例,男44例,女35例,年龄47～78岁。根据入院时间分为Z型不锈钢支架组(n=38)和镍钦记忆合金网状支架组(n=41),两组患者分别采用国产Z型不锈钢和镍钦记忆合金网状支架治疗。支架置入后分别对食管支架可靠性指标、有效性指标、副作用、并发症和材料与组织生物相容性指标进行观察。结果:79例食管癌合并食管狭窄患者全部进入结果分析。可靠性指标评估中,两组患者完全可靠、部分可靠及不可靠例数分布接近,差异无显著性意义(P>0.05)。有效性指标比较中,两组患者完全有效、部分有效及无效例数分布接近,差异无显著性意义(P>0.05)。置入后副作用和并发症指标相比,Z型不锈钢支架组VRS疼痛分级、恶心和呕吐症状发生率明显高于镍钦记忆合金网状支架组(P<0.05～0.01),余下各种副作用和并发症观察指标无显著差异(P>0.05)。支架材料与组织生物相容性指标比较中,两组患者无全身毒性及超敏反应发生,造血系统细胞成分、数目、形态均正常。结论:国产Z型不锈钢和镍钦记忆合金网状支架均较适用于恶性食管狭窄的姑息治疗,但镍钦记忆合金网状支架置入后副作用较少。
AIM： To compare clinical parameters, such as reliability, availability, postoperative side effects, complications, and biocompatibility, between Chinese-made Z-type stainless steel stent and Ni-Ti alloy mesh stent in treating advanced esophageal cancer. METHODS： A total of 79 patients, 44 males and 35 females aged 47 78 years, with advanced esophageal cancer and esophageal stenosis were selected from Department of Digestive Internal Medicine, Henan Hospital of Traditional Chinese Medicine. They underwent surgical treatment of Z-type stainless steel stent （n=-38） and Ni-Ti alloy mesh stent （n=41）. Clinical parameters, such as reliability, availability, side effect, and complication, were observed postoperatively. RESULTS： All 79 patients were included in the final analysis. There were no significant differences in case distribution of entire, partial, and non-reliability between two groups （P 〉 0.05）. Moreover, there were also no significant differences in case distribution of entire, partial, and non-availability between two groups （P 〉 0.05）. However, incidences of VRS paining grade, nausea and vomiting in Z-type stainless steel stent group were significantly higher than Ni-Ti alloy mesh stent group （P 〈 0.05 0.01 ）; while other side effects and complications had no significant differences between the two groups （P 〉 0.05）. All patients in both groups did not have general toxicity and hypersensitivity reaction, and they had normal cell component, number and form of hematopoietic system. CONCLUSION： Both Z-type stainless steel stent and Ni-Ti alloy mesh stent are suitable for alleviative treatment of advanced esophageal cancer; however, side effects induced by Ni-Ti alloy mesh stent is less than by Z-type stainless steel stent in an early postoperative stage.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第4期752-755,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
