摘要
目的探讨足月妊娠孕妇下肢深静脉内径、血液流速及血液指标的变化规律,为孕妇血栓前状态(PTS)的早期诊断及治疗提供临床辅助依据。方法具血栓形成高危因素足月妊娠孕妇A组128例、健康足月妊娠孕妇B组61例及健康非孕妇女C组42例,利用高分辨率彩色多普勒超声(CDU)对3组妇女双下肢深静脉进行检查,同时监测血液学指标D-D、PLT,HGB,HCT,TT,APTT,PT,FbgC值,比较其统计学差异。结果A组与B组比较:左/右侧股静脉(CFV)内径、左侧股浅静脉(SFV)内径显著增宽,左/右侧腘静脉(POPV)血流频谱峰值降低,HCT、D-D增高,差异有统计学意义(P<0.01);左侧POPV内径增宽,差异有统计学意义(P=0.034)。A组、B组分别与C组比较:左/右侧CFV、左/右侧SFV、POPV、胫后静脉(PTV)内径显著增宽,左/右侧CFV血流频谱峰值、左/右侧POPV血流频谱峰值显著降低,血液学指标监测均显著变化,差异有统计学意义(P<0.01)。结论足月妊娠孕妇较健康非孕妇女处于明显的血栓前状态,而具血栓形成高危因素的足月妊娠孕妇较健康足月妊娠孕妇更易处于血栓前状态,双下肢深静脉CDU检查对PTS的诊断有一定的辅助价值。
Objective To explore the changes in lower limb deep vein diameters, blood flow velocity and blood biochemistry in full-term pregnant women for early diagnosis and treatment ofprothrombotic state. Methods One hundred and twenty-eight full-term pregnant women at high risk of thrombosis （Group A）, 61 healthy full-term pregnant women （Group B）, and 42 healthy non-pregnant women （Group C） underwent high-resolution color Doppler ultrasound （CDU） for examining the deep veins of the lower limbs. The hematological indexes such as D-D, PLT, HGB, HCT, TT, APTT, PT, and FbgC were also observed in these 3 groups. Results Compared to Group B, the women in group A showed significantly increased diameters of the common femoral veins （CFV） and left superficial femoral vein （SFV）, HCT and DD, but with significantly decreased peak blood flow in the bilateral popliteal veins （POPV） （P〈0.01） and increased left POPV diameter （P=0.034）. Compared to those in group C, the diameters of the bilateral CFVs, SFVs, POPV, and posterior tibial veins （PTVs） were significantly increased, but the peak blood flow in the bilateral CFVs and POPVs were significantly reduced in groups A and B; the PLT, HGB, HCT, DD, TT, APTT, PT, and FbgC also showed significant changes in groups A and B （P〈0.01）. Conclusion The full-term pregnant women are at higher risk ofprothrombotic state than non-pregnant women, and the full-term pregnant women with the high risk factors for thrombosis are more likely to have prothrombotic state than healthy full-term pregnant women. CDU examination of the lower limb deep veins can be of value in the diagnosis ofprothrombotic state.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2009年第1期23-25,共3页
Journal of Southern Medical University
基金
"十五"国家科技攻关项目(2001BA703B15)
国家"十一五"科技支撑项目(2006BAI01A06)
广东省科技计划项目(2007B030502015)
