摘要
黑素合成和黑素在细胞内的运动是非常复杂而精确的过程,这个过程决定皮肤色素的沉着。黑素细胞和角化细胞转移黑素的机制尚不清楚。黑素细胞的胞吐作用和角化上皮细胞的吞噬作用是黑素传递的最可能的机制。其他的可能机制包括经过黑素细胞释放的包含黑素体的小囊泡,或者经过角化上皮细胞和黑素细胞浆膜的融合形成隧道单位。已经确认的最重要的和转移有关的分子是角化细胞的蛋白酶激活受体2。该分子经过吞噬作用完成黑素的传递。另外黑素传递也可经过E-钙粘蛋白、SNAREs、Rab和RhoGTP酶的活动由外源凝集素和糖蛋白的交互作用来完成。
The synthesis of melanin pigments and the intercellular movement of melanin are complex and precision processes that determine skin pigmentation. The mechanism by which melanocytes and keratinocytes transfer melanin is yet unknown. Exoeytosis of melanocytes and phagocytosis of keratinocytes are the most possible mechanism in melanin transfer. Other plausible mechanisms are transfer via melanosome-containing vesicles shed by the melanocyte or transfer via fusion of keratinocyte and melanocyte plasma membranes with formation of tunneling nanotubes. The most important identified molecules involved in transfer is protease-activated receptor-2 of the keratinocyte which effectuates melanin transfer via phagocytosis. Melanin transfer is also accomplished by the interactions of lectins and glycoproteins, by the action of E-cadherin , SNAREs , Rab and Rho GTPases.
出处
《实用医院临床杂志》
2009年第2期1-3,共3页
Practical Journal of Clinical Medicine
