摘要
目的对医院产超广谱β-内酰胺酶(ESBLs)细菌的检出率及耐药性进行动态观察,为临床应用抗菌药物提供指导。方法对我院2004至2007年临床标本分离的395株大肠埃希菌和262株肺炎克雷伯菌用双纸片扩散法检测其ESBLs,并用纸片扩散法进行药敏试验。结果4年来大肠埃希菌产ESBLs阳性率从25.3%上升至37.7%;肺炎克雷伯菌产ESBLs阳性率从25.0%上升至36.0%。产ESBLs株对头孢菌素类、氟喹诺酮类等常用抗菌药物的耐药率明显高于非产ESBLs株,对碳青霉烯类抗菌药物敏感。结论4年来,大肠埃希菌、肺炎克雷伯菌中ESBLs阳性率逐年升高,并呈现出多重耐药性,对产ESBLs菌株的治疗应首选碳青霉烯类抗菌药物。
Objective To explore the detection rate and the dynamic trend of drug resistance rate of extended spectrum β-1actamases （ESBLs） -producing bacteria for the guidance of rational use of antibiotics. Methods ESBLs in 395 strains of Escherichia coli （ E. coli ） and 262 strains of Klebsiella pneumoniae （ K. pneumoniae ） isolated from clinical samples of our hospital from 2004 to 2007 were detected by double disk synergy test. Meanwhile, the antibiotic resistance in either ESBLs producing or ESBLs non-producing strains were compared and analyzed. Results The positive rates of ESBLs producing E. coil and K. pneumoniae increased from 25.3% and 25.0% in 2004 to 37.7% and 36.0% in 2007, respectively. The ESBLs producing isolates displayed multi-drug resistance to cephalosporins and quinolones. The drug resistance rate was significantly higher than that of the ESBLs non-producing isolates, but both of them were still highly sensitive to carbopenems. Conclusions The positive rates of ESBLs producing E. coli and K. pneumoniae in our hospital were increasing gradually in the past four years and they exhibited multi-drug resistance. Carbopenems antibiotics should be applied firstly to treat the related infections.
出处
《检验医学》
CAS
北大核心
2009年第2期91-93,共3页
Laboratory Medicine
关键词
大肠埃希菌
肺炎克雷伯菌
超广谱Β-内酰胺酶
耐药性
Escherichia coli
Klebsiella pneumoniae
Extended spectrum β-lactamases
Drug resistance
