摘要
目的研究通脉口服液防治早期糖尿病肾病的作用机制。方法采用右肾切除加腹腔一次性注射链脲佐菌素建立糖尿病肾病动物模型。通脉口服液治疗组给予通脉口服液灌胃,正常组和模型组给予等量的蒸馏水灌胃,时间为8周。给药结束后,观察大鼠一般情况、肾脏肥大指数、24h尿量、血糖、尿微量白蛋白、肾功能、血糖、血脂、肾脏病理的变化情况。结果通脉口服液治疗组大鼠的一般情况明显好于模型组,体重明显增长(P<0.01),肾脏肥大指数明显下降(P<0.01),血糖明显下降(P<0.01),血清尿素氮和肌酐明显下降(P<0.01),肾脏病理损害得到明显的改善,24h尿量和血脂无明显变化。结论通脉口服液通过控制血糖和改善肾血流动力学防治Ⅱ期糖尿病肾病。
Objective To investigate the effect of Tongrnai oral liquid on the early diabetic nephropathy. Methods Diabetic nephropathy rats were induced by excision of the right kidney and a single intraperitoneal injection of streptozotocin （STZ）. Forty male Wistar rats were divided randomly into 3 groups： Tongmai group, nephrotic model group, and normal group. At the end of the 8th week, the rats general states and some parameters such as kidney hypertrophy index, 24 h urine volume, blood glucose, 24 h urinary microalbumin （24 h UMA）, renal function [serum creatinine （Cr）, blood urea nitrogen （BUN）], serum lipid, and the change of nephritic pathologic lesion were measured. Result Compared with the model group, general states in Tongmal group were improved, there was a considerable increase on body weight （P〈0.01）. Compared with the model group, there was a significantly decrease （P〈0.01） on the kidney hypertrophy index, blood glucose, BUN and Cr in Tongmal group. The pathologic lesion in kidney morphology were also ameliorated obviously. But there were no remarkable differences in the 24 h urine volume and serum lipid index. Conclusion Tongmai oral liquid can prevent and cure the II period diabetic nephropathy by controlling blood glucose and improving renal hemodynamics.
出处
《中国中医药信息杂志》
CAS
CSCD
2009年第3期32-34,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
中国博士后基金(20070420765)
关键词
Ⅱ期糖尿病’肾病
通脉口服液
药效学
动物模型
Ⅱ period diabetic nephropathy
Tongmal oral liquid
pharmacodynamics
animal model
