摘要
目的比较10 d序贯疗法与传统三联疗法根治幽门螺杆菌(Hp)的疗效与安全性。方法选取85例1月内14C尿素呼气试验阳性或者胃镜Hp实验阳性病例,随机分为两组:治疗组前5 d予奥美拉唑、阿莫西林,后5 d予奥美拉唑、替硝唑、克拉霉素治疗;对照组予奥美拉唑加阿莫西林、克拉霉素治疗10 d。疗程结束1月后行14C尿素呼气试验检测。结果1月后疗程结束时,治疗组总有效率97.6%,对照组总有效率73.3%,两组疗效比较有非常显著性差异(P<0.01);治疗组14C尿素呼气试验转阴率为95.2%,对照组转阴率为76.7%,两组Hp转阴率比较具有显著性差异(P<0.05)。结论10 d序贯疗法治疗Hp的根治率较传统三联疗法高,且副作用少,易耐受,安全可靠。
Objective To compare the efficacy and safety of 10-days sequential treatment（including omeprazole,amoxillin, clarithromycin and tinidazole）and 7 days traditional trigeminy therapy （including omeprazole, amoxillin and clarithromyein ） for the eradication of helicobaeter pylori（Hp）. Methods 85 patients with Hp positive who were detected by 14C urea breath test or gastroscope Hp test were randomly divided into two groups：the therapic group （A group,42 cases） and the control group（ B group,43 cases）. The therapic group was treated with omeprazole,amoxillin at first 5 days, omeprazole, clarithromyein and tinidazole at the second 5 days;while the control group was treated with omeprazole,amoxillin and claritbromycin for 10 days. The 14C urea breath test was detected after course of treatment finished in a month. Results There was significant difference compa- ring the total effective rate of the therapic group and the control group with the rate is 97.6% to 76. 7% （ P 〈0. 01 ） o The eradication rate of 10 days sequential therapy was 95.2% and that of control group was 76.7%, and there was significant difference between two groups（ P 〈 0. 05）. Conclusion 10 days sequential therapy is more effective,well-tolerated and with higher rate of eradication than 7 clays traditional trigeminy therayp.
出处
《临床消化病杂志》
2009年第1期16-17,共2页
Chinese Journal of Clinical Gastroenterology
关键词
10
d序贯疗法
三联疗法
幽门螺杆菌
10 days sequential therayp
Trigeminy therapy
Helicobacter pylori
