摘要
目的评估基因重组卵泡刺激素(rFSH)和尿卵泡刺激素(uFSH)在体外受精-胚胎移植(IVF-ET)和卵胞浆内单精子注射(ICSI)促排卵中的疗效。方法 244例接受IVF和ICSI的不育患者,分为rFSH组103例、uFSH组141例,两组均采用黄体期长方案超促排卵。卵泡监测、取卵、IVF-ET按本中心常规进行。观察用药时间、剂量、费用,获卵数、卵裂率、优胚率、妊娠率及重度卵巢过度刺激综合征(OHSS)发生率等。结果 rFSH组与uFSH组比较,使用FSH安瓿数显著减少(P<0. 05),但费用比uFSH高(P<0. 05),人绒毛膜促性腺激素(hCG)日雌二醇(E_2) rFSH较uFSH高,但无显著差异。两组在获卵数、受精率、卵裂率、优胚率、胚胎种植率、临床妊娠率、流产和OHSS发生率无显著差异(P>0. 05)。结论 uFSH和rFSH促排卵治疗同样有效、安全。
Objective：To evaluate the efficiency of urinary FSH （u-FSH） and recombinant FSH （r-FSH） for controlled ovarian hyperstimulation （COH） in IVF-ET and ICSI-ET treatment. Methods：Two hundred and forty-four infertile women were randomly assigned into the rFSH （n= 103） and uFSH （n= 141） groups for controlled ovarian hyperstimulation in IVF-ICSI cycles. Following a long down-regulation protocol, rFSH or uFSH was administered. Results：The ampoules used in uFSH group were significantly more than those in rFSH group （P〈 0.05）, but the cost was higher in rFSH group （P〈0.05）. Serum estradiol （E2） level on the day of hCG administration was lower in u-FSH group, but with no significant difference （P〉0.05）. There was no significant difference in number of oocytes retrieved, fertilization rate, cleavage rate, fine quality embryo rate, implantation rate, clinical pregnancy rate, total days of FSH stimulation, miscarriage＇and OHSS rate between two groups （P〉0.05）. Conclusion： Urinary FSH is as effective and safe as recombinant FSH for ovarian induction.
出处
《生殖医学杂志》
CAS
2009年第1期14-16,共3页
Journal of Reproductive Medicine
关键词
基因重组
尿卵泡刺激素
控制性超促排卵
Gene recombination
Urinary FSH
Controlled ovarian hyperstimulation.
