摘要
目的探讨无水酒精门静脉栓塞(PVE)对肝硬化的影响。方法正常和肝硬化SD大鼠门脉(PV)内注射无水酒精,观测肝脏解剖、病理、生化以及PV血流动力学的变化。结果 0.05ml/100g注射剂量下正常大鼠存活率100%,肝硬化大鼠仅40.9%。后者接受0.03%ml/100g无水酒精PVE后,非栓塞肝叶肥大显著,肝实质损害轻到中度,肝功能、PV压和血流量变化轻微短暂。结论肝硬化时无水酒精PVE只要剂量适当是安全的,针对栓塞对肝脏的影响可采取相应的保护措施。
Objective To investigate the influences on cirrhotic liver using portal vein embolization (PVE) with ethanol. Methods By injectionf intraportal absolute ethanol in normal and cirrhotic SD rats, the changes in anatomy, pathology, hepatic function as well as portal hemodynamics were observed. Results At a dose of 0.05 ml/100 g of ethanol, the survival rate was 1000% in normal rats whereas only 40.9% in cirrhotic rats. After PVE for the cirrhotic rats with 0.03 ml/100 g of ethanol, it caused significant hypertrophy in non-embolized lobes, mild or moderate damage to the liver parenchyma, slight and transient variations on liver function, portal pressure as well as portal flow. Conclusion PVE with ethanol in the situation of hepatic cirrhosis was safe under an appropriate dose administered and some treatments in relation to pre- serving the liver were preferable.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1998年第1期75-76,共2页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金
