摘要
目的回顾性分析300例早产儿乙肝疫苗接种后的免疫效果。方法300例早产儿按体重分为A、B、C、D4组,按照不同孕周分为E、F组,按照接种剂量分为G、H组。免疫程序为三针法,末次接种后1个月检测Anti-HBs滴度及HBsAg。比较各组Anti-HBs滴度与HBsAg阳性率的变化,分析乙肝疫苗接种后免疫效果的影响因素。结果A、B组间及各组内男孩与女孩间比较,其GMT水平与乙肝疫苗抗体阳转率无明显差别(P>0.05),C、D组的GMT水平与乙肝疫苗抗体阳转率明显高于A、B两组,D组GMT水平与乙肝疫苗抗体阳转率明显高于C组(P<0.01);E组与F组GMT水平与乙肝疫苗抗体阳转率无明显差别(P>0.05);高剂量H组的GMT水平与乙肝疫苗抗体阳转率明显高于低剂量G组(P<0.01);早产儿乙肝疫苗阳转率为79.3%。结论早产儿体重和接种剂量是影响早产儿乙肝疫苗的免疫效果的主要因素之一。
Objective To analyze retrospectively immune response of 300 premature after vaccine inoculation of HBVac. Methods 300 prematures were divided into A, B, C, D, E, F, G, H by body weight, gestational weeks and the dose of vaccine inoculation of HBVac. All premature were received HBVac following O, 1,6months. After immunization,local and systemic reaction were observed and recorded during 72h-after 6 months, Anti-HBs titre and seroconvcrsion rate were measured. Results There were no obviously local and systemic reaction in all groups in which all test were finished successfully. There were no significantly differences between Group A, B（P〉 0.05）. Eroconversion rate of Group C, D Eroconversion rate of Group A and B（P〈 0.01 ）. Eroconversion rate of Group Eroconversion rate of Group G（P〈 0.01 ）. The total Eroconversion rate was 79.3%. Conclusion The body weight and the dose of vaccine inoculation of HBVac is principal factor of effect premature＇s immune response.
出处
《中国现代医生》
2009年第3期74-75,共2页
China Modern Doctor
