摘要
目的:观察盐酸羟考酮控释片(奥施康定)治疗晚期癌症中、重度疼痛的临床效果、不良反应及患者生活质量的改善情况。方法:68例中、重度疼痛患者给予奥施康定镇痛治疗,初始剂量10mg/12h,正在用吗啡类镇痛药者,按照吗啡1/2剂量换算。根据疼痛情况调整剂量,直至患者无痛或基本无痛,每位患者至少治疗l5d以上,同时进行疼痛强度、生活质量评分及不良反应观察。结果:奥施康定的最终滴定剂量为:≤30mg/d的30例(44.1%),31～60mg/d的16例(23.5%),61～120mg/d的l8例(26.5%),≥120mg/d的4例(5.9%)。总疼痛缓解率为95.6%,其中完全缓解27例(39.7%),明显缓解33例(48.5%),中度缓解5例(7.4%)。患者生活质量明显提高,不良反应少且轻微。结论:盐酸羟考酮控释片治疗中、重度癌性疼痛疗效显著,不良反应较少,能显著改善癌症患者的生活质量。
Objective：To evaluate the efficacy and side effects of oxycodone hydrochloride controlled-release tablets in the treatment of moderate to severe pain in patients with terminal cancer and to observe any improvement on the cancer patients quality of life. Methods：Sixty-eight patients with moderate or severe cancer pain were treated with oxycodone hydrochloride controlled release tablets. The initial dose was 10 mg/12h, or 1/2 that of the standard morphine regimen. During the course of treatment,the dosage was adjusted according to the patients desires until the pain completely or nearly disappeared. Each patient received the treatment for at least 15 days. At the same time ,adverse effects ,quality of life and scores for the intensity of pain were observed and recorded. Results：The final titrated dosage of oxyeodone was described as below：30 cases （44.1%） received a dosage of ≤30 mg/d, 16 cases （23.5%）received a dosage of 31 to 60 mg/d, 18 cases（26.5% ）received a dosage of 61 to 120 mg/d and those in 4 cases （5.9%）received a dosage of more than 120 mg/d. The overall relief rate from pain was 95.6% , and the rates of excellent, effective and moderate relief was 39.7%, 48.5% and 7.4%, respectively. Mild side effects and improved quality of life were observed after oxycodone treatment. Conclusions：Oxycodone is effective in treatment of moderate and severe cancer pain. The side effects of oxycodone are mild, and the drug can significantly improve the quality of life for patients with cancer pain.
出处
《中国疼痛医学杂志》
CAS
CSCD
2009年第1期6-8,共3页
Chinese Journal of Pain Medicine
