摘要
目的:对比观察氨酚羟考酮和曲马多用于中、重度偏头痛及紧张性头痛的疗效。方法:52例偏头痛及紧张性头痛患者,按随机数字法分为氨酚羟考酮组(n=25)和曲马多组(n=27)。分别服用氨酚羟考酮胶囊及盐酸曲马多片进行治疗。观察治疗前后数字评分量表(numericratingscales,NRS)评分变化、镇痛有效率及不良反应。结果:服氨酚羟考酮的偏头痛患者(第1组)治疗前后NRS值差异无显著性意义。服曲马多的偏头痛患者(第2组)、服氨酚羟考酮(第3组)和曲马多(第4组)的紧张性头痛患者治疗前NRS值分别为7.48±1.75,6.03±2.47和6.96±2.39,治疗后为3.58±3.26,1.25±1.53和2.32±2.30,均较治疗前明显下降(P<0.01),治疗后第2,3组的NRS值明显低于第1组(第1,2组间比较:t=2.369,P=0.029;第1,3组间比较:t=6.012,P=0.000)。第3组有效率(58%)明显高于第1组(13%)(P=0.020)。各组间副作用发生率差异无显著性意义。结论:氨酚羟考酮用于紧张性头痛的疗效较好,曲马多可用于偏头痛和紧张性头痛,其他药物治疗无效时可考虑选择这两种药物。
AIM:To compare and observe the curative effect of tylox and tramadol in treating moderate to severe migraine and tension headache. METHODS:Fifty two adult patients with moderate to severe migraine and tension headache were divided into tylox group(n=25) and tramadol group(n=27) by random number table method.Patients took one capsule of tylox or one tablet of tramadol orally for treatment.The numeric rating scales(NRS),numeric changes,efficacy rate of relieving pain and the dysreaction were observed before and after treatment. RESULTS:The difference of NRS in patients of hemicrania who took tylox(group 1) did not have obvious significance.The NRS value of the patients of hemicrania who took tramadol(group 2) and the patients of tension headache taking tylox(group 3) or taking tramadol(group 4) were 7.48±1.75,6.03±2.47 and 6.96±2.39,which decreased to 3.58±3.26,1.25±1.53 and 2.32±2.30 after treatment.Each of the values was significantly decreased(P< 0.01),and the NRS values in group 2 and group 3 were obvious lower than that in group 1(comparison between group 1 and group 2:t=2.369,P=0.029;comparison between group 1 and group 3:t=6.012,P=0.000).The efficacy rate in group 3 was significantly higher than that in group 1(13%,P=0.020).The difference of the incidence of side effects among groups was not significant. CONCLUSION:The effect of tylox used for tension headache is better,and tramadol is suitable for migraine and tension headache.Both of them can be used when other drugs cannot control these moderate to severe pains.
出处
《中国临床康复》
CSCD
2004年第32期7081-7083,共3页
Chinese Journal of Clinical Rehabilitation
