摘要
目的评价门冬氨酸钾注射液治疗低钾血症的临床疗效。方法入选患者为上海交通大学医学院附属仁济医院等3家医院2007年3月至2008年5月收治的各种原因引起的低钾血症患者。试验组(42例)给予门冬氨酸钾注射液3mL加入5%葡萄糖注射液(或生理盐水)750mL中静脉滴注,对照组(44例)给予氯化钾注射液2mL加入5%葡萄糖注射液(或生理盐水)750mL中静脉滴注,补钾量均为1.10g/d,每日1次,最长疗程7d。结果治疗后试验组和对照组的临床显效率分别为86.67%和91.11%,两组比较差异无统计学意义(P=0.3998)。试验组血钾值从治疗前的(3.18±0.23)mmol/L升高到治疗结束时的(3.73±0.37)mmol/L,血钾平均升高(0.55±0.37)mmol/L;对照组血钾值从治疗前的(3.17±0.24)mmol/L升高到治疗结束时的(3.78±0.41)mmol/L,血钾平均升高(0.61±0.46)mmol/L,组间比较差异无统计学意义(P=0.4722)。试验组在第2、4和7天时血钾恢复正常的累积率分别为(51.11±7.45)%、(77.78±6.20)%和(86.67±5.07)%,与对照组比较差异无统计学意义(P=0.1430)。结论门冬氨酸钾注射液3mL加入到5%葡萄糖注射液(或生理盐水)750mL中静脉滴注,每日1次,疗程7d的疗效与含有等剂量钾离子的氯化钾注射液相当,可以有效地治疗各种原因引起的低钾血症。
Objective Estimating clinical effects of the Therapy of Potassium L-aspartate Injection on Hypokalemia. Methods These hypolalemia patients from the Renji hospital of Shanghai Jiaotong University and Other Two Hospitals, and from March 2007 to May 2008 ,which were caused from various kinds of reasons. The test group （42 patients） were intravenous dripped by using three rami potassium L-aspartate injection added in 5% Glucose （or saline） 750 mL, the control group （44 patients） were gived two rami chloratum Kalium injection added in 5% Glucose （or saline） 750 mL, the Kalium were 1.10 g/d in both groups, once per day, time of therapy was 7 day. Results The test and control groups effective power after therapy were 86. 67% and 91.11%, respectively, there was no significant difference （P = 0. 3998）. The Kalium dose of test group was advanced from （3. 18 ±0. 23） mmol/L before testing to （3.73 ±0. 37） mmol/L after therapy, the elevated average was （0. 61 ± 0.46） mmol/L, and there was no significant difference （ P = 0. 4722）. The accumulation power of Kalium recovery were （51.11 ± 7.45 ） % , （77. 78 ± 6. 20） %, （ 86. 67 ± 5.07 ） %, at the second, the fored and the sevened day,respectively. There was no significant difference between the two groups （P = 0. 1430）. Conclusion The clinical effect was correspond between three rami potassium L-aspartate injection added in 5% Glucose （or saline） 750 ml and the Isodose chloratum Kalium injection, by once per day, and seven days of therapy, which can treat hypokalimeia caused from various kinds of reasons.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2009年第2期165-166,168,共3页
Chinese Journal of Practical Internal Medicine
关键词
门冬氨酸钾
低钾血症
potassium L-aspartate
hypokalemia
