摘要
目的和方法：对维甲酸预防甲基硝基亚硝基胍（ＭＮＮＧ）诱导体外培养胎胃粘膜上皮细胞恶性转化的作用进行研究。结果：结果发现，胃粘膜细胞先用１０－５Ｍ或１０－６Ｍ维甲酸预处理４小时，再给ＭＮＮＧ组非程序ＤＮＡ合成（ＵＤＳ）水平，质脂过氧化物和ｒａｓＰ２１含量，均显著低于ＭＮＮＧ组（Ｐ＜００５～００１）。结论：结果提示。
Aim and method:The preventive effects of retinoic acid (RA) on fetal Gastric epithelial cells (GEC) in vitro damaged by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) was studied.Results:It was found that the level of unscheduled NDA synthesis (UDS),the contens of lipid peroxidation products and the concentrations of ras P21 in GEC,treated with 10-5 M and 10-6 M RA for 4 hours prior to MNNG administration,decreased obviously,compared with GEC treated without RA,the differences were significant (P<0.05～0.001).Conclusion:Our results indicate that RA can effectively prevent chemical damagte on GEC from MNNG.
出处
《胃肠病学和肝病学杂志》
CAS
1998年第1期72-75,共4页
Chinese Journal of Gastroenterology and Hepatology
