摘要
目的:观察注射用清开灵联合三黄一龙汤治疗类风湿关节炎(RA)活动期的临床疗效。方法:选择RA活动期患者120例,分为清开灵联合中药治疗组60例和非甾体抗炎药(NSAID)对照组60例,观察其临床指标和实验室指标的改善情况,了解其总有效率。结果:治疗组的临床指标和实验室指标的改善明显早于并优于对照组(P<0.01);治疗组治疗2周、4周后总有效率分别为49.76%、90.98%,亦明显优于对照组(P<0.05)。结论:注射用清开灵联合中药以清热解毒、合清三焦湿热法为主治疗RA活动期,与非甾体药物比较,可以缩短起效时间,可以更好地降低关节滑膜的炎症,调节患者的免疫功能,提高其治疗的总有效率。
OBJECTIVE： To observe the clinical efficacy of Qingkailing for Injection in combination with Sanhuang and Earthworm Decoction in treating active stage of rheumatoid arthritis （RA）. METHODS： A total of 120 RA patients were assigned to receive Qingkailing for Injection in combination with Sanhuang and Earthworm Decoction （trial group, n - 60） or non-steroidal anti-inflammatory drug （NSAID） （control group, n = 60）. The clinical and the laboratory indexes and the total effective rates in the two groups were observed. RESULTS： The clinical and laboratory indexes in the trial group showed an earlier and better improvement than in the control group （ P 〈 0.01 ）, and the total effective rates at 2 and 4 weeks after the initiation of the treatment were 49.76 % and 90.98 % respectively, significantly higher than in the control group （ P 〈 0.05）. CONCLUSION： As compared with NSAID, Qingkailing for Injection in combination with Sanhuang and Earthworm Decoction in treating active stage of rheumatoid arthritis （RA） through clearing away the heat-evil and expelling superficial evil and clearing away the damp-heat from the Sanjiao can shorten the effect-onset time, better relieve the inflammation of synovial membrane of joint, regulate patients＇ immunologic function and increase the total effective rate.
出处
《中国医院用药评价与分析》
2009年第1期64-66,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
清开灵
三黄汤
地龙
类风湿关节炎
清热解毒
清三焦湿热
临床研究
Qingkailing
Sanhuang decoction
Earthworm
Rheumatoid arthritis
Clearing away the heat-evil and expelling superficial evil
Clearing away the damp- heat from the Sanjiao
Clinical study
