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RECK基因与头颈部鳞状细胞癌 被引量:2

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摘要 RECK是新发现的一种基质金属蛋白酶家族(matrix metalloproteinases,MMPs)抑制剂和肿瘤抑制基因,它在肿瘤组织中的表达能抑制肿瘤的侵袭和转移。相关研究发现此作用与细胞外基质(extracellular matrix,ECM)、MMPs和金属蛋白酶组织抑制因子(tissue inhibitor of metalloproteinases,TIMPs)密切相关。现就RECK与ECM、MMPs、TIMPs之间的相互作用及其与头颈部鳞状细胞癌(headand neck squamous cell carcinoma,HNSCC)的侵袭和转移关系做一综述,以期为头颈部肿瘤的治疗和研究提供帮助。
出处 《国际耳鼻咽喉头颈外科杂志》 2009年第1期1-3,共3页 International Journal of Otolaryngology-Head and Neck Surgery
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