摘要
目的:合成盐酸达泊西汀。方法:以苯甲醛和丙二酸为原料,经八步反应合成目标化合物。结果:目标化合物经旋光度测定及1H NMR,13C NMR,2D-NMR确证其化学结构,总收率达到15.08%。结论:该合成方法操作简单、收率高、适合工业化生产。
Objective： To synthesize d synthesized from benzaldehyde and malonic ac apoxetine hydrochloride. Methods： Dapoxetine hydrochloride was via eight steps. Results： The chemical structure of the target cornpound was confirmed by ^1H NMR, ^13C NMR and 2D-NMR analyses. The total yield of the target compound was 15.08%. Conclusion： This synthesis is an easily manipulated synthetic process with high yield, and it is also suited for industrialization
出处
《中国新药杂志》
CAS
CSCD
北大核心
2008年第24期2119-2121,共3页
Chinese Journal of New Drugs
