凋亡抑制蛋白家族与血液系统肿瘤的关系研究进展
Progress of relationship between inhibitor of apoptosis protein family and tumor in hematological system
摘要
凋亡抑制蛋白(IAP)家族是细胞凋亡途径中惟一的内源性半胱天冬酶(caspase)抑制物。杆状病毒IAP重复系列是IAP家族成员的共有结构,是发挥抗凋亡作用的关键部位。IAP主要通过抑制caspase家族成员介导的蛋白酶级联反应过程中caspase-3、7、9及caspase前体的活性而发挥抗凋亡作用。IAP家族的表达水平与血液系统恶性肿瘤的发生、发展、分化程度、预后、耐药和治疗效果有关。采用小干扰RNA阻断IAP家族是血液系统恶性肿瘤治疗的新靶点。
出处
《国际儿科学杂志》
2009年第1期79-81,共3页
International Journal of Pediatrics
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