摘要
目的探讨2型糖尿病肾病（DN）患者血清脂联素（APN）和转化生长因子β1（TGF-β1）的水平及二者的相关性。方法选择糖尿病患者120例，根据尿微量白蛋白排泄率（UAER）分为正常白蛋白尿组、微量白蛋白尿组、大量自蛋白尿组，用ELISA方法检测其血清APN和转化生长因子β1（TGF-β1）浓度，同时测定各组的UAER、血糖、血肌酐、糖化血红蛋白等的水平，取正常人34例为对照组。结果（1）血清APN、TGF-β1水平随病程进展逐渐升高，各组间比较差异均有显著性（P〈0．05）。（2）在DN阶段血清APN与TGF-β1水平呈显著正相关，相关系数r=0．449（P〈0．01）。（3）在DN阶段血清APN、TGF-β1水平与UAER、血糖、血肌酐、糖化血红蛋白水平呈正相关。结论APN和TGF-β1可能在DN的发病过程中起重要作用；TGF-β1可作为早期发现DN的一种新的敏感指标；APN、TGF-β1有望成为治疗DN的新靶点。
Objective To measure the level of serum adiponectin（APN） and transforming growth factor betal （ TGF-β1 ） of the type 2 diabetic mellitus patients and study the relationship between the two cytokines. Methods 120 cases of type 2 diabetic mellitus patients were enrolled in this study, according to the level of urinary albumin excretion （UAER）, all the patients were divided into 3 groups：the group of normal albunin ura （ NA group ; UAER 〈 20 ug/min）, the group of micro albunin ura （ MA group ; UAER ： 20-199 ug/min） ,the group of overt diabetic nephropathy（ ODN group;UAER 〉 199 ug/min）. The 34 cases of healthy persons were as normal control. The level of serum adiponectin and transforming growth factor betal of all the patients and normal control persons were measured by ELISA respectively, at the same time the level of UAER, BG, Cr and HbA1 c of all the patients and normal control persons were measured respectively. Results （ I ） In the type 2 diabetic mellitus patients with nephropathy , the level of serum adiponectin and TGF-β1 were gradually increased according to the prolonging of the disease. Among the NA, MA and ODN groups, the differences of serum adiponectin and TGF-β1 were significant respectively（ P 〈0.05 ） ; （2） At the stage of the diabetic mellitus nephropathy （ DN ）, the level of the serum of APN and TGF-β1 was positively correlated, the correlation coefficient was r = 0. 449 （P 〈 0.01 ） ;（ 3 ） At the stage of the DN, the level of the serum of APN and TGF-β1 , the level of UAER, BG, Cr and HbA1 c were also positively correlated. Conclusion APN and TGF-13J may play an important role in the occurrence of the diabetic mellitus nephropathy ;TGF-β1 can be considered as a new sensitive marker to help us to find the DN as earlier as possible;APN and TGF-β1 may be as the new treatment targets of the DN.
出处
《临床内科杂志》
CAS
2009年第1期49-51,共3页
Journal of Clinical Internal Medicine
