摘要
目的:研究颅脑外伤(TBI)后早期补充硫酸镁对TBI的疗效。方法:将我科3年来收治的94例重型TBI患者分为硫酸镁治疗组、硫酸镁+利多卡因治疗组及对照组。硫酸镁治疗组除常规治疗外还给予硫酸镁2g(16mmol)稀释至100mL于15min内推注+硫酸镁7.8g(65mmol)稀释至500mL静滴24h。硫酸镁+利多卡因治疗组除了以上述方法应用硫酸镁外,加用利多卡因1mg/(kg·h)维持24h。对照组除不补充硫酸镁和利多卡因之外其余治疗同以上两组。检测所有患者入院及3d时血镁水平、入院和入院1周时的血神经元烯醇化酶(NSE)含量,6个月后以格拉斯哥预后评分(GOS)来评估各组治疗结果。结果:各组重型TBI患者在受伤后1周时的血NSE水平无明显差异,各组重型TBI患者伤后6个月时GOS的结果无明显差异。结论:本研究未发现TBI后早期补充硫酸镁能明显改善重型TBI的治疗效果。
Objective To evaluate the early use of magnesium sulfate （MgSO4） in traumatic brain injury （TBI） patients. Methods 94 severe TBI patients on conventional therapy were divided to MgSO4 group （ 100 mL of 2% MgSO4 bolus within 15 min and 500 mL of 1.56% MgSO4 solution for 24 hours）, MgSO,/lidocaine group [lidocainc of 1 mg/（kg. h） for 24 hours in addition to the same therapy as MgSO4 group], or contol group （without MgSO4 and lidoeaine）. Serum Mg^2＋ level at admission and on day 3 and plasma NSE level at admission and on day 7 were detected. The effcicacy of each therapy was assessed by Glasgow outeome scale （GOS） 6 months after treatment. Results Plasma NSE level did not differ signifieantly one week after brain injury, nor the scores of GOS 6 months following injury in all patients. Conclusion Early magnesium sulfate therapy ean not markedly imporve the outcomes of severe TBI.
出处
《实用医学杂志》
CAS
北大核心
2009年第2期263-265,共3页
The Journal of Practical Medicine
基金
上海市浦东新区社会发展局卫生科技发展基金资助项目(编号:Pw2004A-16)
关键词
颅脑外伤
硫酸镁
利多卡因
神经元烯醇化酶
Craniocercbral trauma
Magnesium sulfate
Lidocaine
Neuron specific enolase
