摘要
原发性胆汁性肝硬化（PBC）是一种自身免疫性疾病，以肝内胆管进行性破坏、慢性胆汁淤积为主要特征。PBC的发病机制复杂，涉及遗传易感性、免疫机制、感染因素及化学物质等。了解PBC的发病机制对于采取正确合理的治疗方案，降低其发病率和病死率意义重大。其中免疫机制与机体产生的自身抗体及免疫细胞分泌的多种细胞因子相关。本文就免疫因素在PBC发病机制中的作用进行综述。
Primary biliary cirrhosis （PBC） is considered as a typical autoimmune disease characterized by progressive destruction and chronic cholestasis, and its pathogenesis was complexed, including genetic predisposition,immunologic mechanism,infection, chemical substance and so on. It is important to understand pathogenesis of PBC for treatment plan, degrading disease incidence and death rate of PBC. This article reviewed the immune pathogenesis of PBC.
出处
《医学综述》
2009年第2期185-188,共4页
Medical Recapitulate
