摘要
哺乳动物的性别决定是以Sry基因为主导,其它多个基因参与的级联调控的机制。近年来的研究表明,Sry、Sox9、Wt1、Sf1、Amh、Dax1、Dmrt1、Wnt4等基因都参与性别决定的级联过程。哺育动物性别决定相关基因的研究,对性分化与生殖发育过程的了解具有十分重要的意义。主要论述了参与哺乳动物性别决定与调控的相关基因、可能作用机制及其研究进展等。
Mammalian animal sex determination is a cascade process controlled by Sty gene and many other genes participating in. In recent years,to explore the function of mammalian sex-determining gene,a number kinds of genes inchlding Sry,Sox9,Wt1,Sf1,Amh,Dax1,Dmrt1 and Wnt4 have been implicated in the cascade. The research off the sexdetermining genes play an important role in sex differentiation and reproductive development. In this paper,mammalian animal sex determination genes regarding to regulating and controlling,process mechanism and research headway were introduced.
出处
《生物技术通报》
CAS
CSCD
北大核心
2009年第1期40-44,共5页
Biotechnology Bulletin
基金
国家高技术研究发展计划(863计划)(2006AA10Z136)
关键词
性别决定基因
性分化
生殖发育
Sex-determining gene Sex differentiation Reproductive development
