摘要
目的:通过分析上海市胸科医院外科重症监护室(ICU)在《抗菌药物临床应用指导原则》出台前后两年的细菌药敏数据,观察临床控制使用抗菌药物后的效果。方法:采用回顾性分析方法,采集2003年和2005年病原菌和药敏数据,将两年数据进行对比分析。结果:在标本被检出有细菌或真菌的病人数基本相同(2003年59例,2005年58例)的情况下,2005年较2003年细菌耐药率有所下降,特别是对喹诺酮类药物。但铜绿假单胞菌对第三代和第四代头孢菌素耐药率有一定程度的上升。结论:加强临床抗菌药物管理有益于降低临床感染发生率和细菌耐药性。
Objective： To analyze bacteria and drug sensitivity data of surgical intensive care unit （ICU） of Shanghai Chest Hospital in 2003 and 2005, which were the years before and after promulgating the guidelines for clinical application of antibiotics, in order to observe the results of controlling the use of antibiotics. Methods： A retrospective study was performed by collecting and comparing the data of bacteria and drug sensitivity test of surgical ICU in 2003 and 2005. Results： In the condition of same number of patients （59 cases in 2003,58 cases in 2005） whose specimens were found to have bacteria or fungi, bacterial drug-resistance rate in 2005 was lower than that in 2003, especially resistance to quinolones. But the resistance of Pseudornonas aeruginosa to the third- and the fourth-generation cephalosporins was rising. Conclusion： Enhancing the management of the application of anti-bacterials can reduce the rate of clinical infection and bacterial drug-resistance.
出处
《药学服务与研究》
CAS
CSCD
2008年第6期421-424,共4页
Pharmaceutical Care and Research
关键词
抗菌药
重症监护病房
微生物敏感性试验
合理用药
anti-bacterial agent
intensive care unit
microbial sensitivity test
rational use of drug
