摘要
目的:观察养心益肝汤对缺血性中风后遗症期患者血清ET、NO含量的影响。方法:292例缺血性中风后遗症期患者随机分为治疗组154例(用养心益肝汤和常规康复治疗)和对照组138例(用常规康复疗法),观察患者神经功能缺损评分和治疗前后血清内皮素(ET)、一氧化氮(NO)的变化。结果:与治疗前比较,两组治疗后神经功能缺损评分明显降低(P<0.01),治疗组治疗后神经功能缺损评分明显低于对照组(P<0.05);两组治疗后血清NO含量较治疗前显著升高,ET含量较治疗前显著降低(P<0.05或P<0.01);与对照组比较,治疗后治疗组血清NO、ET含量差异有显著性(P<0.05)。结论:养心益肝汤可提高缺血性中风后遗症期患者神经功能,其作用机制与调节NO和ET含量有关。
Objective:To observe the effect of Yangxinyigan Tang on the content of Endothe-lin(ET)and nitric oxide(NO)in blood plasma of patients with ischemic apoplexy sequelae.Methods:292 cases of ischemic apoplexy sequelae were randomly divided into the treatment group of 154(with Yangxinyigan Tang and routine rehabilitation),and the control group of 138(routine rehabilitation),to observe the neurologic impairment scores and the content of ET and NO in blood plasma before and after treatment.Results:after treatment,the neurologic impairment scores were significantly descended in both groups(P<0.01),the neurologic impairment scores in treatment group significantly lower(P<0.05);the contents of NO were increased,and the contents of ET were decreased obviously in both groups(P<0.05 or P<0.01);compared with control group,the ET and NO contents were different obviously in treatment groups(P<0.05).Conclusion:Yangxinyigan Tang could improve neurologic function of patients with ischemic apoplexy sequelae,and the mechanism was related to the content of ET and NO.
出处
《河北中医药学报》
2008年第4期5-7,共3页
Journal of Hebei Traditional Chinese Medicine and Pharmacology
基金
河北省中医药管理局资助项目:No2007206
关键词
养心益肝汤
缺血性中风
内皮素
一氧化氮
Yangxinyigan Tang
Ischemic apoplexy
Endothelin(ET)
Nitric oxide(NO)
