摘要
目的:控制药费增长,促进抗高血压药的合理使用,为消费者选择高血压药物治疗的方案提供参考。方法:通过文献检索,收集并汇总26种常用抗高血压药有效性、安全性的信息;并以各种常用抗高血压药的每月平均药费范围上限为成本,降压有效率为效果,进行成本-效果分析,并在坐标轴中作散点图,寻找效果/成本比良好的品种。结果:抗高血压药总有效率为69.31%,药物不良反应总发生率为14.50%;氢氯噻嗪、卡托普利、阿替洛尔、美托洛尔、吲哒帕胺缓释片、硝苯地平缓释片、依那普利与氢氯噻嗪合用等都属于高效用药的范畴。结论:药物经济学中的效果/成本比可以在成本-效果坐标系中用直线的斜率来体现,鼓励使用基本药物和普通替代药的高效消费的用药行为。
OBJECTIVE To give reference of rational selection of antihypertensive drugs and control raise of medical cost. METHODS Carry out computer retrieval to literature on drug treatment of routine antihypertensive drugs, assemble data and evaluate synthetically to 26 kinds of antihypertensive efficacy and safety; take the toplimit of average drug purchase expense monthly as cost, and effective rate of depressurization as effectiveness, and do scatterplot in coordinate axis in order to compare cost-effectiveness ratio. RESULTS Total effective rate of these drugs is 69. 31 %, and total incidence rate of adverse drug reaction is 14. 50% ; the result of cost-effectiveness analysis reveals., some medication is of high performance, such as hydrochlorothiazide, captopril, atenolol, metoprolol, indapamide slow-release, nifedipine slow-release, combination therapy of enalapril and hydrochlorothiazide, et al. CONCLUSION National essential drugs and some common drugs made in our country should be chosen because of their favourable effect, lower price and major effectiveness/cost ratio; completely, they are able to substitute for those expensive drugs.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第1期54-57,共4页
Chinese Journal of Hospital Pharmacy
关键词
抗高血压药
药物经济学
成本-效果
有效性
安全性
antihypertensive drugs
pharmacoeconomics
cost-effectiveness
efficacy
safety
