摘要
抑癌基因RUNX3在胃癌中被发现以来,研究便集中在该基因与消化系肿瘤发生发展的关系,尤其是在胃癌、结直肠癌、食管癌、肝癌中.RUNX3基因甲基化可能与肿瘤发生相关,沉默的RUNX3基因重新表达能抑制肿瘤的生长,血浆中甲基化的RUNX3可能成为较敏感的标志物,对于提高消化系肿瘤的早期诊断率将有一定的临床意义.
Since tumor suppressor gene RUNX3 was found in gastric cancer,researches have focused on the relationship between the gene and malignancies in digestive track,especially gastric carcinoma,colorectal carcinoma,esophageal carcinoma and liver carcinoma.The methylation of RUNX3 gene may correlate with the occurence of tumors.Silence of RUNX3 gene can suppress tumor growth,and methylated RUNX3 gene product in serum may be a sensitive tumor marker,which is of great significance in early diagnosis of digestive system neoplasm.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第33期3787-3791,共5页
World Chinese Journal of Digestology
关键词
抑癌基因
RUNX3
消化系肿瘤
Tumor suppressor gene
RUNX3
Di-gestive system neoplasm
