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艾滋病抗病毒治疗新药的研究进展 被引量:10

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摘要 高效联合抗逆转录病毒治疗(HAART)能够阻断人类免疫缺陷病毒(HIV)的复制,恢复艾滋病(AIDS)病人的免疫功能,是目前治疗艾滋病的唯一有效手段。近年来艾滋病抗病毒治疗新药研究取得较大进展,有多种新的抗HIV药物为艾滋病的临床治疗提供更多选择,其中既有针对逆转录酶和蛋白酶的新型抑制剂,也包括对整合酶、辅助受体等新靶点的药物。该文针对新近获准应用于临床和有望进入临床的新药作一综述。
作者 谢静 李太生
出处 《中国艾滋病性病》 CAS 2008年第6期631-633,共3页 Chinese Journal of Aids & STD
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  • 1Autran B, Carcelain G, Li TS, et al.Positive effects of combined antiretroviral therapy on CD4^+ T cell homeostasis and function in advanced HIV disease[J]. Science, 1997,277(5322 : 112 - 116. 被引量:1
  • 2Li TS, Tubiana R, Katlama C, et al. Long-lasting recovery in CD4^+ T cell function and viral load reduction after highly active antiretroviral therapy in advanced HIV disease[ J ]. Lancet, 1998,351 (9117) : 1682 -1686. 被引量:1
  • 3Miller M ,Witmer M, Stillmock K, et al. Biochemical and antiviral activity of MK-O518,a potent HIV integrase inhibitor[C]. 16th International AIDS Conference; Toronto, Canada, Aug 13 - 18 2006. Abstract THAA0302. 被引量:1
  • 4Hazuda DJ, Felock P, Witmer M, et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells[J]. Science,2000,287(5453) :646 - 650. 被引量:1
  • 5Markowitz M, Nguyen BY, Gotuzzo E, et al. Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study[J]. J Acquir Immune Defic Syndr,2007,46(2) : 125 - 133. 被引量:1
  • 6Grinsztejn B, Nguyen BY, Katlama C, et al, Safety and efficacy of the HIV-1 integrase inhibitor raltegravir(MK-0518)in treatment-experienced patients with multidrug-resistant virus: a phase Ⅱ randomised controlled trial[ J ] . Lancet, 2007,369 ( 9569 ) : 1261 - 1269. 被引量:1
  • 7Cooper D, Gatell J, Rockstroh J, et al. 48-week results from BENCHMRK - 1 ,a phase Ⅲ study of raltegravir in patients failing ART with triple-class resistant HIV-1 [ C]. The 15th Conference on Retroviruses ans Opportunistic Infections. Boston, 2008, Abstract 788. 被引量:1
  • 8Steigbigel R, Kumar P, Eron J, et al. 48-week results from BENCHMRK-2 ,a phase Ⅲ study of raltegravir in patients failing ART with triple-class resistant HIV-1 [ C]. The 15th Conference on Retroviruses and Opportunistic Infections. Boston,2008, Abstract 789. 被引量:1
  • 9DeJesus E, Berger D, Markowitz M, et al. Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS- 9137 (JTK-303) in treatment-naive and treatment-experienced patients [J].J Acquir Immune Defic Syndr,2006,43(1) :1-5. 被引量:1
  • 10Zolopa AIR, Mullen M, Berger D, et al. The HIV Integrase Inhibitor GS-9137 Demonstrates Potent Antiretroviral Activity in Treatmentexperienced Patients[C] .The 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles,2007,Abstract 143LB. 被引量:1

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