摘要
The chitosan nanosphere is formed by the ion gel and charactered by TEM.The encapsulation efficiency and controlled release of chitosan nanoparticles for BSA are studied.The result suggests that the high encapsulation efficiency and loading of BSA reach 86% and 49%,the BSA encapsulation efficiency and the BSA loading are affected by the initial CS concentration and the initial BSA concentration,the higher the initial CS concentration,the higher the BSA encapsulation efficiency and the BSA loading.However,it shows opposite trend when the initial BSA concentration increase.The BSA loading increase,but the encapsulation efficiency decrease.The TPP concentration has little influence on BSA encapsulation efficiency.The behavior of chitosan nanospheres for BSA in vitro release revealed a controlled and continuous release of the entrapped protein after 12 hours and released 30% of the BSA loading within 3 hours.
The chitosan nanosphere is formed by the ion gel and charaetered by TEM. The encapsulation efficiency and controlled release of chitosan nanoparticles for BSA are studied. The result suggests that the high encapsulation efifiency and loading of BSA reach 86% and 49% ,the BSA encapsulation efficiency and the BSA loading are affected by the initial CS concentration and the initial BSA concentration, the higher the initial CS concentration, the higher the BSA encapsulation efficiency and the BSA loading. However, it shows opposite trend when the initial BSA concentration increase. The BSA loading increase, but the encapsulation efficiency decrease. The TPP concentration has httle influence on BSA encapsulation efficiency. The behavior of ehitosan nanospheres for BSA in vitro release revealed a controlled and continuous release of the entrapped protein after 12 hours and released 30% of the BSA loading within 3 hours.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2008年第12期1617-1621,共5页
Chemical Research and Application
基金
国家自然科学基金(20765003/B050106)
江西省自然科学基金(0620071)
江西省教育厅科技项目(赣教技字[2007]168号)
航空高校科研基金(EA200502138)资助项目
关键词
壳聚糖
纳米微球
牛血清蛋白
包封
缓释
chitosan
nanosphere
bovine senan albumin
encapsulation efficiency
controlled release
