摘要
目的:探讨大豆蛋白对大鼠炎症因子水平和IR状态的影响,以初步阐明大豆蛋白改善大鼠脂代谢的可能机制。方法:SD雄性大鼠分为阴性对照组、高脂对照组和大豆蛋白组,以相应饲料连续喂养8周,检测3组动物FBG和血脂指标、FINS、IL-6、TNF-α和hs-CRP。结果:与高脂对照组比较,大豆蛋白能显著降低大鼠血清TC、TG、CRP、TNF-α、IL-6、FBG及FINS水平,但HDL-C则没有显著性差异。结论:大豆蛋白可能通过有效的降低脂代谢紊乱大鼠血清炎症因子水平,改善胰岛素敏感性,从而降低大鼠血浆胆固醇的含量,最终改善大鼠的脂代谢水平。
Objective： To investigate the effects of soybean protein on the concentration of inflammatory factors and insulin resistance in rats and to study the possible mechanism of them. Method： Male SD rats were divided into 3 groups and feed for 8 weeks, examines FBG, blood lipid index, FINS, IL-6, TNF-α and hs-CRP. Result： Compared with the control group, the soy protein can obviously reduce serum TC, TG, CRP, TNF-α, IL-6, FBG and FINS（P〈0.01）, but HDL-C did not have the significance difference（P〉0.05）. Conclusion： Soy protein possibly reduced serum inflammation factors level of rats, improved insulin sensitivity and reduced blood plasma cholesterol, improved lipid metabolism level of rats finally.
出处
《食品科技》
CAS
北大核心
2008年第12期183-186,共4页
Food Science and Technology
基金
国家自然科学基金面上项目(30471451)
江苏省社会发展科技基金项目(BS2006047)
关键词
大豆蛋白
脂代谢紊乱
炎症因子
soybean protein
lipid dysmetabolism
inflammatory factors
