摘要
目的:探讨白介素-7(IL-7)与原发性高血压血管内皮功能改变之间的关系。方法:50例实验组分为高血压病1级组25例,高血压病合并冠心病组25例。另设正常对照组20例。使用酶联免疫吸附法进行各组血清IL-7与血管内皮生长因子(VEGF)浓度测定,同时测定血糖、血脂,比较各组间检测指标的差异。结果:(1)高血压组血清IL-7含量(105.30±15.77)pg/ml及VEGF含量(13.58±3.55)ng/ml均高于正常对照组IL-7含量(70.14±6.45)pg/ml及VEGF含量(2.58±0.66)ng/ml(P均<0.01);(2)高血压病合并冠心病组,血清IL-7含量(119.62±6.41)pg/ml与VEGF含量(16.18±2.57)ng/ml,均高于高血压病1级组的IL-7(90.91±4.89)pg/ml与VEGF(6.98±2.25)ng/ml,以及正常对照组(P均<0.01);(3)高血压病1级组、高血压合并冠心病组的VEGF水平与IL-7浓度呈正相关(r=0.481,P<0.05;r=0.558,P<0.01)结论:血清IL-7水平升高与VEGF水平升高呈正相关,可能参与了原发性高血压的发生、发展。
Objective： To study the relationship between Interleukin-7 （IL-7） and changes of blood vessel endothelial growth factor （VEGF） in patients with essential hypertension （EH）. Methods： Experiment group （50 subjects） included the hypertension class t patients group （25 subjects） and hypertension complicated coronary artery disease （CAD） group （25 subjects）. Twenty health control subjects were studied. Use the method of enzyme-linked immunoassay to detect the concentration of serum IL-7, VEGF. Blood sugar and blood fat also detected. The detection indexes were compared with each group. Results.. （1） In the hypertension group, serum IL--7 content was （105.30± 15.77） pg/ml and VEGF was （13.58±3.55） ng/ml. While in the health control group, serum IL-7 was （70.14±6.45） pg/ml and VEGF was （2.58±0. 66） ng/ml. So those of hypertension group were higher than those of health control group （P〈0.01）; （2） The serum IL--7 （119.62±6.41） pg/ml and VEGF （16.18±2.57） ng/ml in hypertension complicated CAD group were higher than those of hypertension group [serum IL--7 （90.91±4. 89） pg/ml and VEGF （6.98±2.25） ng/ml] and health control group （P〈0.01）. （3） The serum VEGF of hypertension group was positive correlated with IL--7 （r=0. 481, P〈0.05）. The serum VEGF of hypertension complicated CAD group was positive correlated with IL-7 （r=0. 558, P〈0.01）. Conclusion： The serum IL--7 level increases and positive correlates with VEGF in hypertension patients, it suggests that IL-7 and VEGF possibly participate the development of essential hypertension.
出处
《心血管康复医学杂志》
CAS
2008年第6期538-541,531,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
白细胞介素
高血压
冠状动脉疾病
血管内皮生长因子类
Interleukins
Hypertension
Coronary artery disease
Vascular endothelial growth factors
