摘要
The chemokine fractalkine primarily involves in chemotaxis,adherence and inflammation.Recently it has been discovered owning the ability of inhibiting cell death in neurons and glial cells,as well as protecting central nervous system from toxic damage.Fractalkine reduces the toxicity to neurons and glial cells mediated by excessive Fas L,glutamate(Glu) or lipopolysaccharide(LPS).In vivo neutralization of endogenous brain fractalkine signal pathway increases inflammatory cytokines secretion and neuronal cell death induced by LPS.Fractalkine may achieve its neuroprotective property through influencing expression of pro-apoptotic and anti-apoptotic proteins,intracellular Ca2+ level and inflammatory cytokines secretion via protein kinase B(PKB)/Akt and extracellular signal-regulated kinase(ERK)/MAPK pathways.
The chemokine fractalkine primarily involves in chemotaxis, adherence and inflammation. Recently it has been discovered owning the ability of inhibiting cell death in neurons and glial cells, as well as protecting central nervous system from toxic damage. Fractalkine reduces the toxicity to neurons and glial cells mediated by excessive Fas L, glutamate （Glu） or lipopolysaccharide （LPS）. In vivo neutralization of endogenous brain fractalkine signal pathway increases inflammatory eytokines secretion and neuronal cell death induced by LPS. Fractalkine may achieve its neuroprotective property through influencing expression of pro -apeptotic and anti -apoptotic proteins, intracellular Ca^2＋ level and inflammatory eytokines secretion via protein kinase B （PKB）/Akt and extracellular signal -regulated kinase （ERK）/MAPK pathways.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2008年第12期2484-2487,2492,共5页
Chinese Journal of Pathophysiology
基金
浙江省自然科学基金资助项目(No.Y204331)
