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PUMA的促凋亡作用与肿瘤治疗 被引量：2

Promoting Apoptotic Effect of PUMA and Tumor Therapy
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摘要 p53上调凋亡调控因子(PUMA)是具有强大促凋亡作用的Bcl-2家族BH3-only亚家族成员。它可以通过p53依赖途径及非依赖途径促进细胞凋亡,在肿瘤的发生过程中及治疗中发挥着重要作用。PUMA的作用与p53状态无关,可能成为人类肿瘤治疗的新靶点。 PUMA （ p53 up-regulated modulator of apoptosis） PUMA is a member of the BH-3-only group of Bcl-2 family protein, which plays a prominent role in promoting apoptosis. PUMA acts as an essential mediator of apoptosis via p53-dependent and p53-independent mechanisms. The function of PUMA has irrelevant to the status of p53 ,which suggests that PUMA can potentially be used as a new target for anticancer therapy.
作者 陈韵如 王玉明 段勇
机构地区 昆明医学院第一附属医院检验科
出处 《医学综述》 2008年第24期3713-3716,共4页 Medical Recapitulate
关键词 p53上调凋亡调控因子 凋亡 肿瘤 P53 p53 up-regulated modulator of apoptosis Apoptosis Tumor p53
分类号 R730.58 [医药卫生—肿瘤] R329 [医药卫生—临床医学]
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参考文献27

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二级参考文献18

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共引文献9

同被引文献34

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医学综述
2008年 第24期

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