摘要
目的:探讨PUMA(p53 up-regulated modulator of apoptosis,P53上调凋亡调控因子)蛋白在皮肤鳞状细胞癌中的表达及意义。方法:采用免疫组化SP法观察36例皮肤鳞癌组织和25例正常皮肤组织石蜡标本中PUMA蛋白的表达情况。结果:皮肤鳞状细胞癌(SCC)组织中PUMA蛋白阳性表达率(25.18%)明显低于正常皮肤组织(78.00%)(P<0.05);SCC中低分化组的PUMA蛋白的阳性表达率低于高分化组(P<0.05)。结论:PUMA蛋白表达下调可能使细胞恶性转化和增殖。
Objective To investigate the expression and significance of PUMA protein in cutaneous squamous cell carcinoma. Methods Expression of PUMA protein was detected in 36 SCC and 25 normal skin specimens by SP immunohistochemical technique. Results The positive rate of PUMA protein was significantly lower in SCC (41.18%) than that in normal skin (100%)( <0.05).The positive rate of P- ERK was significantly higher in SCC(76.47%) than that in normal skin(20.00%)( <0.05).The positive rate of PUMA protein in the low differentiation group were lower than it in the high differentiation group( <0.05). Conclusion The decrease or deletion of PUMA protein expression will result in the malignant transformation and proliferation.
出处
《中国美容医学》
CAS
2015年第1期27-29,共3页
Chinese Journal of Aesthetic Medicine
