1Gentry A,Venkatachalam S. Complicating the role of p53 in aging[J]. Aging Cell, 2005 ;4(3) :157-60. 被引量:1
2Garcia-Cao I, Garcia-Cao M, Martin-Caballero J, et al. “Super p53” mice exhibit enhanced DNA damage response, are tumor resistant and age normally [J]. EMBO J ,2002 ;21 ( 22 ) :6225-35. 被引量:1
3Mendrysa SM, Mcelwee MK, Michalowski J,et al. Mdm2 is critical for in- hibition of p53 during lymphopoiesis and the response to ionizing radiation[ J ]. Mol Cell Biol, 2003 ;23 (2) :462-73. 被引量:1
4Mendrysa SM, O'leary KA, Mcelwee MK, et al. Tumor suppression and normal aging in mice with constitutively high p53 activity [J]. Genes Dev ,2006 ;20( 1 ) : 16-21. 被引量:1
5Yin Y, Stephen CW, Luciani MG,et al. p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products[J].Nat Cell Biol,2002;4(6):462-7. 被引量:1
6Courtois S, Verhaegh G, North S, et al. DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53 [J].Oncogene, 2002 ;21 (44) :6722-8. 被引量:1
7Fabbro M, Henderson BR. Regulation of tumor suppressors by nuclear-cy- toplasmic shuttling [J].Exp Cell Res,2003 ;282 (2) :59 -69. 被引量:1
8Lynette M, Xiongbin Lu, Nader G, et al. Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability,localization, and activity[J].Mech Ageing Dev,2007 ; 128 ( 11-12 ) :717-30. 被引量:1
9Shirangi TR, Zaika A, Moll UM. Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage [ J ]. FASEB J, 2002 ; 16 (3) :420-2. 被引量:1
10yon Mikecz A. The nuclear ubiquitin-proteasome system[J].J Cell Sci, 2006 ; 119 ( Pt 10) : 1977-84. 被引量:1
5Matoba S, Kang JG, Patino WD, et al. p53 regulates mitochondrial respiration[J]. Science,2006 ;312 : 1650-3. 被引量:1
6Bensand K,Tsuruta A,Selak MA,et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis[J].Cell,2006 ; 126 : 107-20. 被引量:1
7Finkel T, Serrano M, Blasco MA. The common biology of cancer and ageing[J].Nature,2007 ;8:767-74. 被引量:1
8Chipuk JE, Kuwana T, Bouchier-Hayes L, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis [J]. Science ,2004 ;5660 : 1010-4. 被引量:1
9Mihara M, Erster S, Zaika A, et al. p53 has a direct apoptogenic role at the mitochondria[J]. Mol Cell ,2003 ;3:577-90. 被引量:1
10Jiang P, Du W J, Heese K, et al. The Bad guy cooperates with good cop p53:Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis[J].Mol Cell Biol,2006 ; 23:9071-82. 被引量:1