摘要
目的:观察原发性高血压患者外周血白介素-6(IL-6)基因表达,初步探讨其与原发性高血压的关系及其意义。方法:用放射免疫法测定62例原发性高血压患者和30例正常对照者外周血IL-6蛋白含量,用逆转录聚合酶链反应法检测外周血单个核细胞中IL-6 mRNA表达。结果:与对照组比较,原发性高血压组患者外周血IL-6蛋白水平及外周血单个核细胞中IL-6 mRNA表达均显著增高(P<0.01)。结论:IL-6可能参与了原发性高血压的病理生理过程,外周血单个核细胞的IL-6 mRNA表达上调可能是原发性高血压患者外周血IL-6蛋白水平升高的机制之一。
Objective： To observe the expression changs of interleukin-6 （IL-6） in peripherial blood of patients with essential hypertension （ EH）, and to probe the relationgship between IL-6 mRNA level and EH. Methods： The concentrations of circulating IL-6 of 62 EH patients （ group EH） and 30 normal people （group CN） were measured by using radioimmunoassay, and the expression of mRNA of IL-6 in mononuclear cells was measured with reverse transcription polymerase chain reaction. Results： The concentration of protein IL-6 in peripherial blood and IL-6 mRNA in mononuclear cell of group EH were significantly higher than those of group CN （P 〈0.01 ）. Conclusions： IL-6 might participate the patho-physiology process of EH. nisms increasing protein IL-6 in ; Up-regulating expression of IL-6 mRNA may be one of the mecha- peripher/al blood of EH patient.
出处
《贵阳医学院学报》
CAS
2008年第6期665-667,共3页
Journal of Guiyang Medical College
基金
贵阳市科学技术计划资助项目[2006筑科农字27-5号]
