期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

溶酶体中GAG抗氧化应激诱导细胞凋亡的信号传导通路 被引量：4

Signal transduction pathways of GAG in lysosome which inhibits apoptosis induced by oxidative stress
下载PDF
导出
摘要 在氧化应激诱导细胞凋亡过程中,溶酶体中的葡萄糖胺聚糖(GAG)具有在早期溶酶体水平负调控细胞凋亡的作用。本文重点阐述溶酶体中葡萄糖胺聚糖抗氧化应激诱导细胞凋亡作用的信号传导通路。 Glycosaminoglycan（GAG） has recently become an important landscape of discovering new mechanisms of apoptosis stressed by oxidative stress. In this review, we focused the signal transduction passways of GAG in lysosome which can inhibit apoptosis induced by oxidative stress.
作者 张甘霖 岳晓莉 李萍
机构地区 首都医科大学附属北京中医医院北京市中医研究所 北京中医药大学病理教研室 法国巴黎第十二大学
出处 《基础医学与临床》 CSCD 北大核心 2008年第11期1223-1225,共3页 Basic and Clinical Medicine
关键词 氧化应激 葡萄糖胺聚糖 细胞凋亡 oxidative stress glycosaminoglycan apoptosis
分类号 R341 [医药卫生—基础医学]
  • 相关文献

参考文献10

  • 1Nicholas J, Cartel MP. Abrogation of apoptosis through PDGF-BB-induced sulfated glycosaminoglycan synthesis and secrdtion [ J]. AJP-lung Cell Mod Physiol, 2005, 288:285 - 293. 被引量：1
  • 2Laurent G, Jaffrezou JP. Signaling pathways activated by daunorubicin[J]. Blood, 2001, 98(4): 913-924. 被引量：1
  • 3Puduvalli VK, Sampath D, Bruner JM, et al. TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation [ J ]. Apoptosis, 2005, 10(1) :233 -243. 被引量：1
  • 4林跃辉,王敏.PI3-K-AKT信号转导途径与凋亡的关系[J].国际病理科学与临床杂志,2005,25(4):307-310. 被引量：25
  • 5Kagedal K, Johansson AC, Johansson U, et al. Lysosomal membrane permeabilization during apoptosis involvement of Bax? [J]. In J E Pathol, 2005, 86(5) : 309 - 321. 被引量：1
  • 6Chwieralski CE, Wehe T, Buhling F. Cathepsin-regulated apoptosis [ J ]. Apoptosis. 2006, 11 (2) : 143 - 149. 被引量：1
  • 7Nicholas J, Santos AS, Eric D, et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death [J]. Nature, 2001,410:549-554. 被引量：1
  • 8Campo GM, Avenoso A, Campo S, et al. Chondroitin sulphate: antioxidant properties and beneficial effects [ J ]. Mini Rev Med Chem, 2006, 6 (12) : 1311 - 1320. 被引量：1
  • 9Campo GM, Avenoso A, D'Ascola A, et al. Purified human plasma glycosaminoglycans limit oxidative injury induced by iron plus ascorbate in skin fibroblast cultures [ J ]. Toxicol In Vitro, 2005, 19(5) : 561 -572. 被引量：1
  • 10Campo GM, Avenoso A, Campo S, et al. Reduction of DNA fragmentation and hydroxyl radical production by hyaluronic acid and chondroitin-4-sulphate in iron plus ascorbate-induced oxidative stress in fibroblast cultures [ J]. Free Radic Res, 2004, 38(6) :601 -611. 被引量：1

二级参考文献20

  • 1Thoompson JE, Thompson CB. Puttingthe Rap on Akt [ J]. J Clin Oncol, 2004,1522 ( 20 ) :4217-4226. 被引量：1
  • 2Zhou HL, Li XM, Meinkoth J, et al. Akt Regulates Cell Survival and Apoptosis at a Postmitochondrial Level [ J ]. J Cell Biol, 2000,151 (3) :483-494. 被引量：1
  • 3Feng J,Tamaskovic R, Yang Z, et al. Stabilization of Mdm-2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation [ J ]. J Biol Chem, 2004,279 ( 34 ): 35510-35517. 被引量：1
  • 4Downwrd J. PI 3-kinase, Akt and cell survival[J]. Semin Cell Dev Biol, 2004,15(2) :177-182. 被引量：1
  • 5Chang F, Lee JT, Navolanic PM, et al. Involvement of PI3-K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy [ J ]. Leukemia, 2003,17(3) :590-603. 被引量：1
  • 6Franke TF, Hornik CP, Segev L, et al. PI3-K/Akt and apoptosis:size matter[J]. Oncogene, 2003,22(56) :8983-8998. 被引量：1
  • 7Derouet M,Thomas L, Cross A, et al. Granulocyte Macrophage Colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1 [ J ]. J Biol Chem, 2004,279(26) :26915-26921. 被引量：1
  • 8Cowburn AS, Cadwallader KA, Reed B J, et al. Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokinemediated neutrophil survival[ J]. Blood, 2002,100:2607-2616. 被引量：1
  • 9Blanca Scheijen, Hai T Ngo, Hyun Kang, et al. FLT3 receptors with intenal Tandem duplications promote cell viability and proliferation by signaling through Foxo proteins [ J ]. Oncogene, 2004,23 ( 19 ):3338-3349. 被引量：1
  • 10Takada Y, Kobayashi Y, Aggarwal BB. Evodiamine abolishes constitutive and inducible NF-kappa B activation by inhibiting I kappa B alpha kinase activation, thereby suppressing NF-kappa B-regulated antiapoptotic and metastatic gene expression, upregulating apoptosis,and inhibiting invasion [ J ]. J Biol Chem, 2005,280 ( 17 ): 17203-12. 被引量：1

共引文献24

同被引文献15

引证文献4

二级引证文献15

基础医学与临床
2008年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部