摘要
目的观察氟伐他汀治疗对冠心病患者妊娠相关血浆蛋白-A(PAPP-A)和氧化型低密度脂蛋白(ox-LDL)水平的影响。方法选择冠心病组患者75例,包括急性心肌梗死(AMI)患者32例,不稳定型心绞痛(UAP)患者22例和稳定型心绞痛(SAP)患者21例。正常对照组60例。采用双抗体夹心酶联免疫吸附试验检测冠心病患者PAPP-A和ox-LDL水平。结果PAPP-A在急性冠脉综合征组(ACS,包括AMI、UAP)浓度较SAP及正常对照组均明显偏高(P<0.05);ox-LDL在冠心病组中的浓度较正常对照组高(P<0.05),且在AMI、UAP、SAP各组组间比较均有显著性差异(P<0.05);氟伐他汀治疗后冠心病患者PAPP-A和ox-LDL浓度均显著下降(P<0.01);PAPP-A与ox-LDL水平呈正相关(P<0.01)。结论氟伐他汀治疗后冠心病患者PAPP-A和ox-LDL浓度降低,氟伐他汀可能通过抑制炎症反应,减少氧化应激来发挥心血管的保护作用。
AIM To observe the effect of fluvastatin on PAPP-A and ox-LDL levels in patients with coronary heart disease. METHODS Seventy-five patients with coronary heart disease were divided into acute myocardial infarction （n = 32） , unstable angina pectoris （ n = 22） and stable angina pectoris （ n = 21 ） groups, and 60 subjects without coronary disease were used as controls. The serum PAPP-A and ox-LDL were detected by ELISA. RESULTS The level of PAPP-A in acute coronary syndrome （ACS, including acute myocardial infarction and unstable angina pectoris） patients was significantly higher than those in stable angina pectoris patients and controls （P 〈 0.05）. The level of ox-LDL in patients with coronary heart disease was significantly higher than that in controls （P 〈 0.05）, with significant difference between AMI, UAP and SAP groups （P 〈 0. 05）. After the treatment with fluvastatin, the levels of PAPP-A and ox-LDL markedly decreased （P 〈 0. 01 ） and the level of PAPP-A was positive correlated with that of ox-LDL （P 〈 0. 01 ）. CONCLUSION After fluvastatin treatment, the levels of PAPP-A and ox-LDL greatly decrease in coronary heart disease group. Fluvastatin has a protective effect on heart by repressing inflammatory reaction and attenuating oxidative stress.
出处
《心脏杂志》
CAS
2008年第6期711-713,共3页
Chinese Heart Journal
