摘要
目的探讨阿托伐他汀干预对急性冠脉综合征(ACS)患者血清高敏C反应蛋白(hs-CRP)和妊娠相关血浆蛋白-A(PAPP-A)水平的影响。方法采用酶联免疫吸附法测定不稳定型心绞痛患者(UAP,n=37)、急性心肌梗死患者(AMI,n=24)、稳定型心绞痛患者(SAP,n=29)和健康体检者(n=32)的hs-CRP和PAPP-A水平。同时将ACS患者(包括UAP和AMI组,n=61)随机分为常规治疗组(n=30)和阿托伐他汀干预组(阿托伐他汀10mg/d,n=31),并于治疗前后分别测定血清hs-CRP和PAPP-A水平。结果(1)hs-CRP和PAPP-A水平在UAP组[(16.7±1.24)mg/L,(63.88±1.82)μg/L]、AMI组[(18.52±1.96)mg/L,(66.41±1.24)μg/L]比SAP组[(4.6±1.16)mg/L,(47.56±0.72)μg/L]、正常对照组[(3.2±0.88)mg/L,(45.17±1.28)μg/L]显著升高(P<0.05)。(2)2周后,阿托伐他汀干预组血清hs-CRP和PAPP-A水平较治疗前明显降低[hs-CRP(18.52±2.37)mg/Lvs.(3.58±1.33)mg/L;PAPP-A(67.83±2.15)μg/Lvs.(45.62±1.58)μg/L,P<0.05],且较常规治疗组治疗2周后亦有显著降低[hs-CRP(3.58±1.33)mg/Lvs.(5.23±1.98)mg/L;PAPP-A(45.62±1.58)μg/Lvs.(51.35±2.15)μg/L,P<0.05]。结论阿托伐他汀干预可以减少急性冠脉综合征患者动脉粥样硬化斑块的炎症反应,具有稳定斑块的作用。
Objective To investigate the effects of atorvastatin on serum high sensitive C-reactive protein （hs-CRP） and pregnancy-associated plasma protein-A （PAPP-A） levels in acute coronary syndrome （ACS） patients. Methods Serum hs-CRP and PAPP-A levels were measured in 37 patients with unstable angina （UAP）, 24 patients with acute myocardial infarction （AMI）, 29 patients with stable angina （SAP）, and 32 healthy controls. Sixty-one ACS patients （UAP ＋AMI） were randomly assigned to conventional treatment group （n = 30） or atorvastatin treatment group （n=31）. Serum hs-CRP and PAPP-A levels were detected before and after treatment. Results （1） hs-CRP and PAPP A levels in ACS patients [UAP： （ 16.7 ± 1.24） mg, （ 63.88 ± 1.82 ）μg/L; AMI： （ 18.52 ±1.96）mg/L, （66.41 ± 1.24）μg/L] were significantly higher than those in stable angina patients [（4.6 ± 1.16） mg/L, （47.56±0.72） μg/L] and controls [（3. 2±0. 88） mg/L, （45.17±1.28） μg/L]（all P〈0.05）. （2）Serum hs-CRP and PAPP-A levels were significantly decreased after atorvastatin treatment in ACS group compared with baseline[bs-CRP（18.52±2.37）mg/Lvs. （3.58±1.33） mg/L;PAPP-A （67.83±2.15） μg/Lvs. （45.62±1.58） μg/L; both P〈0.05] and were also lower compared with conventional treatment group [hs-CRP（3.58± 1.33） mg/Lvs. （5.23 ± 1.98）mg/L;PAPP-A（45.62±1.58） μg/L vs. （51.35!2.15） μg/L,both P〈0.05]. Conclusions Atorvastatin can reduce inflammatory reaction in atheroselerotic plaque in ACS patients and has an effect on plaque stabilization.
出处
《中国心血管杂志》
2008年第2期86-89,共4页
Chinese Journal of Cardiovascular Medicine
关键词
阿托伐他汀
急性冠脉综合征
高敏C反应蛋白
妊娠相关血浆蛋白-A
炎症
Atorvastatin： Acute coronary syndrome
High sensitive C reactive protein
Pregnancy associated plasma protein A
Inflammation
