摘要
目的:研究载脂蛋白A5基因-1131T→C多态性位点各基因型及等位基因的分布频率及其与2型糖尿病视网膜病变的关系。方法:应用聚合酶链反应限制性片段长度多态性检测102例糖尿病视网膜病变患者载脂蛋白A5基因-1131TT、TC及CC基因型出现的频率,并与120例无糖尿病视网膜病变患者和150例正常对照组比较。结果:2型糖尿病组等位基因C携带者三酰甘油水平明显高于C非携带者;无糖尿病视网膜病变组和糖尿病视网膜病变组C等位基因的频率高于正常对照组,糖尿病视网膜病变组C等位基因的频率高于无糖尿病视网膜病变组,但无统计学意义。结论:C等位基因与罹患2型糖尿病有关,可能是湖北汉族人群2型糖尿病的独立危险因素之一;与糖尿病视网膜病变的关系尚待进一步研究。
Objective To analyze the relationship between apolipoprotein A5 gene polymorphism and type 2 diabetic mellitus retinopathy. Methods The frequency of the-1131 T→C polymorphism of apolipoprotein A5 gene in 102 patients with type 2 diabetes mellitus retinopathy（DR group） was explored by PC RFLP, and compared with 120 patients with non-diabetic retinopathy（NDR group） and 150 normal controls. Results In DR group, the level of trigalloyl glycerol was higher in allele C carriers than in non C carriers（P〈0.05）. The frequency of the C allele was higher in NDR and DR group than in control group （P〈0.05）, the frequency of the C allele was higher in NDR than in DR group, but there was no statistic difference（P〉0.05）. Conclusion APOA5 -1131 allele C is associated with type 2 diabetic mellitus. The C allele may be an independent risk factor of type 2 diabetic mellitus in Hubei Han population, but its relationship with diabetic retinopathy needs further study.
出处
《中华实用诊断与治疗杂志》
2008年第11期815-817,I0001,共4页
Journal of Chinese Practical Diagnosis and Therapy
