摘要
目的观察中药复方固本祛风汤对变应性鼻炎模型动物豚鼠免疫功能的影响。方法90只健康豚鼠,随机分为6组。以卵清蛋白致敏激发制备变应性鼻炎模型,然后予以中药复方固本祛风汤进行干预治疗,平行设立辛芩颗粒对照组。治疗2周后,测定各组动物血清IgE、IL-4和IFN-γ含量并进行组间比较。结果固本祛风汤治疗组血清总IgE、IL-4水平明显低于模型组(P<0.01),IFN-γ水平则明显高于模型组(P<0.05)。结论固本祛风汤可能通过调节Th1和Th2细胞因子的表达平衡而发挥对变应性鼻炎的治疗作用。
Objective To investigate the effects of Gubenqufeng decoction （GBQFD） on the immune function of guinea pigs with allergic rhinitis （AR） based on an experimental study. Methods Ninety healthy guinea pigs were randomly divided into 6 groups, with OVA plus alumina used to prepare AR model among them. Following the AR model successfully prepared, GBQFD was used to intervene with the modeling animals for two weeks, with Xinqin granule taken as the controlling reagent. By the end of experimental period, sertLm samples were taken from the animals in each group to detect the levels of total IgE, IL-4 and IFN-T, with a comparative analysis among vsoups to see the differences in these indicators. Results The serum levels of total IgE and IL-4 were significantly lower in the treating group with GBQFD than those in modeling group （P〈0.01）, while the serum level of IFN-y was significantly higher in GBQFD treating group than that in modeling group （P〈0.05）. Conclusion It should be possible for Gubenqufeng decoction to bring about the therapeutic effect on AR through its regulatory mechanism to recovery the balance of cytokines between the two sets of lymphocytes Th1 and Th2.
出处
《中国中西医结合耳鼻咽喉科杂志》
2008年第5期331-334,共4页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
基金
深圳市科技局项目(编号200404324)
关键词
变应性鼻炎
固本祛风汤
细胞因子
疗效机制
Allergic rhinitis
Gubenqufeng decoction
Cytokines
Therapeutic mechanism
