摘要
目的探讨长期氯氮平治疗男性精神分裂症病人的身体质量指数(BMI)与精神病理症状的关系。方法对222例长期氯氮平治疗的慢性男性精神分裂症病人进行横断面调查,检测病人的身高和体重,并记录病人服药情况。同时用PANSS量表检测其精神病理症状。结果与正常人群的BMI分布相比,长期氯氮平治疗病人超重和肥胖的比例明显增加(P<0.05)。以BMI进行分组,肥胖、超重、正常体重组和低体重组之间PANSS阴性症状量表(P<0.001)、一般病理症状量表(P<0.05)和总分(P<0.001)之间均存在显著差异。与正常体重组和低体重组相比,肥胖组和超重组在PANSS阴性症状量表、一般病理症状量表和总分上均较低(P<0.05,P<0.01)。Pearson相关分析表明:BMI与PANSS总分(r=-0.248,df=222,P=0.000)PANSS阴性症状量表分(r=-0.256,df=222,P=0.000)和一般病理症状量表分均呈显著负相关(r=-0.19,df=222,P=0.004),而与PANSS阳性症状无显著相关(P=0.23)。结论长期服用氯氮平的男性精神分裂症病人BMI明显增加;而且病人BMI越高,其临床症状、尤其是阴性症状和一般病理症状就越轻。
Objective To explore the relationship between the body mass index （BMI） of male schizophrenic patients long -- term treated by clozapine and the psychiatric symptoms. Methods 222 chronic schizophrenics long--term treated by clozapine were measured for the body height and body mass, the drug administration was recorded, and the patho--symptoms were assessed with the Positive and Negative Syndrome Scale （PANSS） simultaneously. Results Compared with health adults, the proportion of overweight and corpulent patients significantly increased （P 〈 0.05）. Patients were divided into the corpulence group, the overweight group, the normal weight group and the low weight group ac- cording to BMI. There were significant difference in the score of negative symptom subscale （P〈0. 001）, the score of general symptom scale and the total scores among the four groups （P 〈 0.05）. Compared with the normal weight group and the low weight group, the total score, the N scale score and the G scale score of the corpulence group and the overweight group reduced （P 〈 0.05, P 〈 0.01）. There were negative correlations among BMI and negative symptom subscale score （ r =-0. 256, df= 222, P =0. 000）, general symptom score （ r =-0.19, df=222, P =0. 004） and the total scores （ r = -0. 248, df=222, P =0. 000）. There was no correlation between BMI and the positive symptom scale score （ P =0.23）. Conclusions The BMI of patients long--term treated by clozapine significantly increases. The larger of BMI, the less of clinical symptoms, especially negative symptoms and general patho-- symptoms.
出处
《神经疾病与精神卫生》
2008年第5期351-354,共4页
Journal of Neuroscience and Mental Health
基金
北京市自然科学基金(7072035)
美国斯坦利医学研究院基金(03T-459)资助
