摘要
[目的]观察鲜葛花汁对大鼠急性酒精性肝损伤的预防保护作用。[方法]以单味葛花汤、益肝灵为对照,各组大鼠均先给予相应的药物灌胃,0.5 h后以白酒灌胃造成急性酒精性肝损伤模型,每天2次,连续灌胃7 d,第7天处死全部大鼠,检测血清和肝组织丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST),同时光镜观察肝组织病理形态学的改变。[结果]鲜葛花汁能有效降低急性酒精性肝损伤模型大鼠血清及肝组织ALT、AST的升高,且作用显著优于对照组(P<0.01);同时对大鼠肝组织病理形态学改变具有明显改善作用。[结论]鲜葛花汁可用于治疗酒精及其他原因引起的肝损伤。
[Objective]To explore the protective effect of gehua fresh juice on rats with acute hepatic damage caused by alcohol. [Methods]Compared with single gehua decoction and Yiganling, all of rats were first perfused with corresponding drugs, and then perfused with white wine to cause acute alcoholic liver damage. On the 7^th day rats were sacrificed completely, and ALT, AST in sera and tissues were assayed. Simultaneously pathologic change of liver were examined. [Results] Gehua fresh juice could effectively inhibit the elevation of ALT and AST in acute alcoholic hepatic damage, which is superior to the control groups（P〈0. 01）; it also could significantly ameliorate the damages of liver tissue. [Conclusion]Gehua fresh juice may be recommended for treating hepatic damage caused by alcoholism and other causes.
出处
《中国中西医结合消化杂志》
CAS
2008年第5期315-318,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
武汉市卫生局临床科研课题资助项目(WZ08A01)
关键词
鲜葛花汁
肝损伤
急性酒精性
肝组织
gehua fresh juice
acute alcoholic hepatic damage
liver tissue.
