摘要
目的探讨介入检查和治疗过程中水化联合小剂量多巴胺对对比剂肾病的预防作用。资料与方法选择140例于2008年3月至2008年9月接受冠状动脉造影检查或治疗的患者,将其随机分为水化联合小剂量多巴胺研究组和水化治疗对照组。在水化治疗的基础上,研究组同时给予小剂量多巴胺(2μg·kg-1·min-1)。检测所有患者术前、术后第2天、第3天血清肌酐(Crea)水平。结果研究组有3例(4.29%)发生对比剂肾病,对照组有11例(15.7%)。两组比较差异有统计学意义(P<0.05)。结论与单纯水化治疗相比,水化联合小剂量多巴胺可更显著地减少对比剂对肾功能的损害,对对比剂肾病的发生有一定的预防保护作用。
Objective To study the prevention of strengthened rehydration combine with low-dose dopamine therapy to patients with cardiovascular vessel disease from contrast induced nephropathy（CIN）after the interventional therapy.Materials and Methods Totally 140 patients who received coronary angiography from March,2008 to September,2008 were randomly divided into two groups in this study：the hydration combined with low dose dopamine group and the control group.On the basis of hydration therapy,the treated group received strengthened hydration combine with low-dose dopamine（2 μg·kg-1·min-1）treatment.The levels of serum creatinine were measured before and 2,3 days after percutaneous coronary intervention.Results There were 3 cases（4.29%）of contrast induced nephropathy in the hydration combine with low-dose dopamine group as compared to 11 cases（15.7%）in the control group,which had significant difference（P0.05）.Conclusion The strengthened hydration combine with low-dose dopamine therapy can effectively prevent from contrast induced nephropathy,and have some preventive and protective value to patients with CIN.
出处
《临床放射学杂志》
CSCD
北大核心
2011年第4期592-594,共3页
Journal of Clinical Radiology
关键词
冠状动脉介入治疗
水化
小剂量多巴胺
对比剂肾病
Percutaneous coronary intervention Hydration Low-dose dopamine Contrast-induced nephropathy
