摘要
微量白蛋白尿是糖尿病、心血管病和进行性肾损害重要的危险因素。微量白蛋白尿是白蛋白在肾小球滤过屏障中通过增加所致,这不仅仅是肾小球的压力或滤过率的改变,而主要是肾小球超微结构发生改变所致。糖尿病患者体内内皮多糖蛋白复合物的丢失可能与此有关,另外活性氧簇、炎性细胞因子和生长因子也是其关键作用物。
Microalbuminuria is an important risk factor for diabetes,cardiovascular disease and progressive renal impairment. Microalbuminuria arises from the passage of albumin through the glomerular filtration barrier. This requires uhrastructural changes rather than alterations in glomerular pressure or filtration rate alone. The loss of systemic endothelial glycocalyx-a protein-rich surface layer on the endothelium-in diabetes suggests that damage to this layer represents this missing link. Also, reactive oxygen species, inflammatory cytokines and growth factors are key in this pathophysiological mechanism.
出处
《医学综述》
2008年第21期3304-3307,共4页
Medical Recapitulate
