摘要
目的构建雌性实验猕猴宏观情绪与微观指标间非线性方程,为揭示中医肝主疏泄理论提供实验材料支撑。方法采用猴群不同地位层级模式判别标准化方案筛选不同地位猕猴进入实验,应用《雌性实验猕猴情绪评价量表》对猕猴情绪变化予以量化,采集猕猴血尿指标进行神经介质及性激素及其调节激素检测,通过数学建模手段构建宏微观指标非线性方程。结果肝气逆证猕猴模型5-HT含量与愤怒情绪呈非典型负相关,随5-HT含量增加,愤怒情绪积分呈下降趋势,但当5-HT含量上升到一定程度时,愤怒情绪积分反而上升。P含量增加,愤怒情绪积分呈下降趋势,前期下降较快,后期下降较慢。结论情绪与体内微观指标间关系复杂,情绪变化波动可能与体内P、PRL、5-HT等含量变化关系密切。
Objective Construct nonlinear equation between emotion and micro-index using female experimental macaque to provide subject supporting for revealing the famous TCM theory of ＂liver controlling dispersion＂. Methods Adopt the project described by Carol A.Shively to select different status macaque enter experiment,use Emotional Evaluation Scale about Female Experiment Macaque to score macaques＇ emotion,collect blood and urine to test transmitter and hormone content in vivo, and construct nonlinear equation by using mathematics modeling method. Results The liver-qi invasion macaques had a atypia negative correlation between 5-HT content and indignation emotion,while with the increasing of P content, the score of indignation factor descended rapidly in protophase and slowly in anaphase applying Scale method to investigate the relationship of expression＆behaviour and transmitter＆hormone level in vivo on macaques model. Conclusion There is a very complicated relationship between emotion and micro-index in vivo, and the emotion fluctuation maybe related to P, PRL, 5-HT content in vivo closely.
出处
《实验动物与比较医学》
CAS
2008年第5期282-288,共7页
Laboratory Animal and Comparative Medicine
基金
国家自然科学基金资助课题:经前期烦躁易怒与γ-氨基丁酸A受体亚基变化(C03050103)
关键词
PMS肝气逆证
肝气郁证
量表
非线性方程
PMS Liver-qi Invasion
Liver-qi Depression
Scale
Nonlinear equation
