摘要
目的:寻找一种新型的、安全有效的防治绝经后骨质疏松的办法。方法:对北京市罗庄里小区28例49—65岁绝经后妇女进行问卷调查、腰椎骨密度(BMD)、双侧股骨上端BMD,护骨素(OPG)、抗酒石酸酸性磷酸酶(TRAP)和骨特异性磷酸酶(BALP)等测定。随机分为实验组和对照组,实验组采用振动干预,对照组无任何干预。振动方案为:频率30—45Hz、20min/次,3次/周,连续3个月。结果:在实验前和实验后,组间对比BMD均无明显变化。组内对比,实验组腰椎和股骨上端BMD较实验前无明显改变(P=0.397);而对照组左侧股骨上端BMD和双侧股骨BMD均值均较实验前降低0.01g/cm2(P<0.05);实验组与对照组血清TRAP、BALP、OPG在振动干预结束后较实验前均无明显变化。两组血清TRAP、OPG在实验前后分别进行组间对比也无明显变化(P>0.05);而实验前,实验组BALP明显高于对照组5.61μg/L(P<0.05),但3个月后,差异扩大到6.42μg/L(P<0.01),但两组的变化值间没有明显差异(P>0.05)。结论:振动方案对绝经后女性血清BALP、TRAP、OPG无明显影响,但可延缓股骨上端骨丢失。
Objective： To find a new, safe and effective method to prevent or cure osteoporosis （OP） in postmenopausal women. Method： Twenty-eight postmenopausal women were randomized to either vibration group or control group. DEXA was applied to measure these subjects＇ BMD of lumbar spine and both side upper part of femora. Subjects＇ bone mineral metabolism mark [tartrate-resistant acid phosphatase （TRAP）, bone-specific alkaline phosphatase （BALP）, osteoprotegerin （OPG）] in blood serum were measured. Result： ①There was no significant change of BMD between vibration group and control group before and after experiment. After experiment, in control group BMD of left femur and average BMD of both side femora reduced significantly （P〈0.05）. ②No significant change was observed in TRAP, BALP and OPG between two groups before and after experiment. Between these two groups, there was significant difference of BALP before training （P〈0.05）; but after three months training, the difference of BALP became very significant （P〈0.01）. Conclusion： The whole body vibration could not provide obvious effect on TRAP, BALP and OPG level in postmenopausal women, but could prevent bone loss on femora.
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2008年第10期875-877,883,共4页
Chinese Journal of Rehabilitation Medicine
基金
北京市运动机能与评定重点实验室对外开放课题
关键词
全身振动
骨密度
护骨素
抗酒石酸酸性磷酸酶
骨特异性碱性磷酸酶
whole body vibration
bone mineral density
osteoprotegerin
tartrate-resistant acid phosphatase
bonespecific alkaline phosphatase
