摘要
从构效关系角度对大黄中存在的天然蒽醌衍生物进行综述。该类蒽醌衍生物具有相同的母核,因此体现出一些相同的药理活性,但因取代基的不同而表现出活性强度的不同。这些蒽醌衍生物在抗氧化,抗菌,抗癌,对免疫功能的影响等方面存在明显的构效关系,表现为活性的强度与取代基的氧化程度。
It review the structure-function relationship of natural anthraquinone derivatives from Radix et Rhizoma Rhei. The anthraquinone derivatives had many identical activities because they have the identical mother nucleus ; but the strength of their activities were different, because they have different substitution groups. The anthraquinone derivatives shown the obvious structure-function relationship in many respects, such as antioxygenation, antibiosis, anticancer, the influence of immunity and so on.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2008年第20期2424-2427,共4页
China Journal of Chinese Materia Medica
基金
国家中医药管理局留学回国人员科技项目(国中医药研2006LHR06号)
关键词
大黄
蒽醌衍生物
构效关系
Radix et Rhizoma Rhei
anthraquinone derivative
structure-function relationship
