摘要
心肌细胞膜及血管壁上存在大量的阿片受体,以δ和κ为主,这两种阿片受体激动剂在缺血/再灌注过程中可减轻心肌坏死程度并产生抗心律失常的作用;其不仅能模拟缺血预处理,而且对缺血/再灌注心肌有直接保护作用;在缺血后处理的保护作用中也发挥着极其重要的效应。本文对其在缺血/再灌注损伤中的上述三方面保护作用的最新进展进行综述。
Myocardial membrane and vascular wall had a large number of opioid receptors, and K and δ are the most. Both κ and δ opioid receptor agonists may reduce tbe severity of myocardial injury and have antiarrhythmic effect in the process of ischemia/reperfusion. They can not only simulate isehemic preconditioning, but also play a direct protective role in myocardial ischemia/reperfusion, and can offer myocardial protection in the treatment of ischemic postconditioning. This paper reviews the new development of the protective effects of the above - mentioned three aspects for myocardial ischemia/repeffusion injury.
出处
《中国急救医学》
CAS
CSCD
北大核心
2008年第10期940-942,共3页
Chinese Journal of Critical Care Medicine
关键词
缺血/冉灌注损伤
阿片受体
激动剂
心肌保护
Ischemia/repeffusion injury
Opioid receptor
Agonist
Myocardial protection
