摘要
[目的]实验观察溶血现象对丙戊酸钠、卡马西平、苯巴比妥等几种抗癫痫药的血药浓度测定结果的影响。[方法]用注射器针头搅拌血样,建立溶血模型;采用荧光偏振免疫分析法,分别测定溶血前、后血样的血药浓度,结果进行双侧配对t检验。[结果]各品种、各浓度的血样溶血前、后的血药浓度,配对t检验结果为P>0.05,差异无显著性意义。[结论]溶血现象对丙戊酸钠、卡马西平、苯巴比妥的血药浓度测定没有影响,可按常规方法测定。
[Objective] To study the effect of hemolysis in antiepileptics plasma sample determined by FPIA.[Methods]The hemolysis model was built by milling blood sample with injector.The antiepileptics concentrations results of determination in normal samples were compared with that in the hemolysis samples.Statistics of the results is paired-sample T test.[Results]There was no significant statistic difference between the determination results of the normal sample and the hemolysis ones（P〉0.05）.[Conclusion]There was no effect of hemolysis in antiepileptics plasma sample determined by FPIA,This kind of samples can be determinated by regular means.
出处
《大连医科大学学报》
CAS
2008年第5期454-455,共2页
Journal of Dalian Medical University
