摘要
目的探讨老年轻度认知功能损害(MCI)的干预治疗。方法治疗组MCI患者45例,给予安理申5mg/d,共6个月,同期对照组44例,两组均给予饮食、运动、中药等治疗,同时控制其它高危因素(高血压、糖尿病、心血管疾病)等。结果安理申组较对照组简易智能状态检测量表(NMSE)评分显著改善(P<0.05),日常生活自理量表(ADL)评分改善较为明显(P<0.01)。诱发电位P300波幅显著提高;潜伏期缩短(P<0.01)。安理申组有6例出现头晕、恶心等轻度不良反应,继续用药症状解除。结论安理申能有效改善轻度认知功能损害(MCI)患者的认知功能、日常生活自理能力和减轻痴呆程度,不良反应小,耐受性好。
Objective To detect the treatment in agedness with Mild cognitive impeirment（MCI）. Methods 45 patients of MCI in experiment group given aricept per day for 6 months, and 44 patients in controlled group were treated with food, exercise, Chinese medicine, and controlled the other dangerous factors （ hypertension, diabetes, heart disease ,etc ）. Results The grades of Minimental state examination（ MMSE） are improved in experiment group than that in controlled group（ P 〈 0.05） .The grades of Activities of daily living scale（ ADL） are also improved in experiment group than that in controlled group（ P 〈 0.01 ） The amplitude of event - related potentials P300 is heightened and the delitescence in is shortened in experiment group than that in controlled group. Some mild adverse reactions for example dizziness, nausea, etc, were appeared in 6 patients of experiment group but that were disappeared by keeping on the experiment. Conclusion Aricept can effectively improve the cognized function and the ability to daily life in the patients with MCI,and it can alleviate the dementia degree with mild adverse reactions and good tolerance.
出处
《四川医学》
CAS
2008年第10期1320-1322,共3页
Sichuan Medical Journal
关键词
轻度认知功能损害
胆碱酯酶抑制剂
mild cognitive impairment（MCI）
cholinesterase inhibitor（aricept）
