摘要
目的:观察尾叶香茶菜中提取的六种二萜类化合物对人肝癌细胞株SMMC-7721的作用。方法:通过体外细胞培养并应用MTT法分析二萜类化合物对细胞存活率的影响。结果:二萜类化合物B、C、F可明显抑制SMMC-7721细胞增殖,且呈时间剂量依赖性。结论:本研究证明尾叶香茶菜来源的二萜类化合物具有抗肿瘤活性,为尾叶香茶菜的开发利用提供了翔实的实验依据。
Objective To determine the apoptosis of human hepatoma carcinoma cell line S MMC -7721 induced by six kinds of deterpenoids. Method The apoptotic rate of SMMC -7721 cells was detected by MTT and the cell cultured in vitro. Results Diterpenoid B ,C and F could induce the apoptosis of SMMC - 7721 in a dose - and time - dependent manner. Conclusion Diterpenoid B, C and F can trigger the apoptosis of SMMC -7721 through oxidative stress pathway, providing full and accurate experimental basis for using Rabdosia excise.
出处
《吉林医学》
CAS
2008年第19期1608-1610,共3页
Jilin Medical Journal
关键词
二萜类化合物
尾叶香茶菜
肝癌
Diterpenoid
Rabdosia excise
Hepatoma carcinoma
